Core B is as an administrative and database management core that will serve all four projects. This core will provide two vital functions which are essential to the research program. First, the core will provide program- specific administrative support including coordinating interactions between projects, organizing regular monthly meetings of all the project leaders and personnel, overseeing expenditures, and organizing all scientific advisory board meetings. The second main function of this core is to generate and maintain a web database for entry and compilation of data on cell populations in different tissue sites by all project groups by customization using Chemcart(TM), an existing software platform in the CCTI. These datasets will then be collated and uploaded at discrete points in the project to ImmPort, an NIAID-supported Immunology Database and Analysis Portal, to make the novel results and findings from this program on human tissue immune responses freely available and accessible to the scientific community at large. The successful integration of projects and data will depend on an effective core supporting all projects together.

Public Health Relevance

The goal of the research program is a novel examination of human immune cells in tissue sites where immune responses are initiated and maintained, using a unique tissue resource of the Program. The administrative and database core is essential for the coordination of investigators and maintenance of a database for all projects to enter their unique datasets to be made available to the immunology community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI106697-02
Application #
8703319
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$165,566
Indirect Cost
$35,221
Name
Columbia University
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Monticelli, Laurel A; Buck, Michael D; Flamar, Anne-Laure et al. (2016) Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol 17:656-65
Rak, Gregory D; Osborne, Lisa C; Siracusa, Mark C et al. (2016) IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing. J Invest Dermatol 136:487-96
Thome, Joseph J C; Bickham, Kara L; Ohmura, Yoshiaki et al. (2016) Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues. Nat Med 22:72-7
Murray, Alexandra J; Kwon, Kyungyoon J; Farber, Donna L et al. (2016) The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence. J Immunol 197:407-17
Farber, Donna L; Netea, Mihai G; Radbruch, Andreas et al. (2016) Immunological memory: lessons from the past and a look to the future. Nat Rev Immunol 16:124-8
DeWolf, Susan; Shen, Yufeng; Sykes, Megan (2016) A New Window into the Human Alloresponse. Transplantation 100:1639-49
Weiner, Joshua; Zuber, Julien; Shonts, Brittany et al. (2016) Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation. Transplantation :
Tait Wojno, Elia D; Artis, David (2016) Emerging concepts and future challenges in innate lymphoid cell biology. J Exp Med 213:2229-2248
Sonnenberg, Gregory F; Artis, David (2015) Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med 21:698-708
Monticelli, Laurel A; Osborne, Lisa C; Noti, Mario et al. (2015) IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc Natl Acad Sci U S A 112:10762-7

Showing the most recent 10 out of 41 publications