Core B is as an administrative and database management core that will serve all four projects. This core will provide two vital functions which are essential to the research program. First, the core will provide program- specific administrative support including coordinating interactions between projects, organizing regular monthly meetings of all the project leaders and personnel, overseeing expenditures, and organizing all scientific advisory board meetings. The second main function of this core is to generate and maintain a web database for entry and compilation of data on cell populations in different tissue sites by all project groups by customization using Chemcart(TM), an existing software platform in the CCTI. These datasets will then be collated and uploaded at discrete points in the project to ImmPort, an NIAID-supported Immunology Database and Analysis Portal, to make the novel results and findings from this program on human tissue immune responses freely available and accessible to the scientific community at large. The successful integration of projects and data will depend on an effective core supporting all projects together.
The goal of the research program is a novel examination of human immune cells in tissue sites where immune responses are initiated and maintained, using a unique tissue resource of the Program. The administrative and database core is essential for the coordination of investigators and maintenance of a database for all projects to enter their unique datasets to be made available to the immunology community.
|Rosenfeld, Aaron M; Meng, Wenzhao; Luning Prak, Eline T et al. (2018) ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data. Front Immunol 9:2107|
|Kumar, Brahma V; Connors, Thomas J; Farber, Donna L (2018) Human T Cell Development, Localization, and Function throughout Life. Immunity 48:202-213|
|Carpenter, D J; Granot, T; Matsuoka, N et al. (2018) Human immunology studies using organ donors: Impact of clinical variations on immune parameters in tissues and circulation. Am J Transplant 18:74-88|
|DeWolf, Susan; Grinshpun, Boris; Savage, Thomas et al. (2018) Quantifying size and diversity of the human T cell alloresponse. JCI Insight 3:|
|Senda, Takashi; Dogra, Pranay; Granot, Tomer et al. (2018) Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunol :|
|Vander Heiden, Jason Anthony; Marquez, Susanna; Marthandan, Nishanth et al. (2018) AIRR Community Standardized Representations for Annotated Immune Repertoires. Front Immunol 9:2206|
|Chu, Coco; Moriyama, Saya; Li, Zhi et al. (2018) Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183. Cell Rep 23:3750-3758|
|Miron, Michelle; Kumar, Brahma V; Meng, Wenzhao et al. (2018) Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life. J Immunol 201:2132-2140|
|Rosenfeld, Aaron M; Meng, Wenzhao; Chen, Dora Y et al. (2018) Computational Evaluation of B-Cell Clone Sizes in Bulk Populations. Front Immunol 9:1472|
|Fu, Jianing; Zuber, Julien; Martinez, Mercedes et al. (2018) Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool. Cell Stem Cell :|
Showing the most recent 10 out of 63 publications