The Human Sample Core C will be responsible for: 1) collection and preparation of clinical samples and lung specimens; 2) evaluation of vaccine candidates in human primary epithelial cells; and 3) measuring serum RSV antibodies from human and cotton rat samples. It will support and interact with all 4 Projects and the Animal Core B included in this P01. Thus, this Core will serve two main goals. First, it will assure the quality of the human samples, and it will simplify streamlining sample organization, data management and compliance with all regulations. Second, this core will be responsible for: a) running the in vitro primary cell culture assays to evaluate vaccine candidates generated by Projects 1, 2 and 3; and b) measuring serum RSV antibodies in serum samples obtained from infants included in Project 4 and from experimental infections in cotton rats performed in the Animal Core B. This approach will optimize the use of resources and will facilitate integration and synergy among all projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI112524-04
Application #
9541792
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Kim, Sonnie
Project Start
Project End
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
147212963
City
Columbus
State
OH
Country
United States
Zip Code
43205
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Mejias, Asuncion; Garcia-Maurino, Cristina; Rodriguez-Fernandez, Rosa et al. (2017) Development and clinical applications of novel antibodies for prevention and treatment of respiratory syncytial virus infection. Vaccine 35:496-502
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Ngwuta, Joan O; Chen, Man; Modjarrad, Kayvon et al. (2015) Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Sci Transl Med 7:309ra162