The Pediatric Rheumatology Informatics Core is a funded component of a P30 Rheumatic Disease Core Center and a major contributor to the past success of the P01program. This core provides biomedical informatics expertise and infrastructure to the Cincinnati Rheumatic Diseases Core Center Research Base at the Cincinnati Children's Research Foundation of Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine. Because of the continued need for extensive microarray data management and analysis support by the proposed P01program, we are proposing to continue to fund a supplement to the Informatics Core. The purpose of the supplement will be to provide adequate bioinformatics infrastructure, expertise and hands on assistance for specific data management and analysis needs of the 4 P01 projects. The core will provide tailored analysis support to individual projects and perform integrative analyses of all data generated throughout the project. The Core will employ standardized, state- of-the-art protocols for management and analysis of microarray data and develop innovative statistical learning approaches for constructing and validating predictive transcriptional signatures. Altogether, the Core will facilitate the use of optimal data analysis procedures by integrating current relevant methodological, biological and clinical insights. The core will also facilitate the meaningful access to data by the scientific community through the development of new JIA Genomics Data Portal (, and provide biostatistical support to research projects as needed. The three aims of the core are: 1) To provide research projects with the comprehensive Bioinformatics support for management, analysis and interpretation of DNA microarray data;2) To develop the JIA genomics data portal ( as the community resource for meaningful access to genomics data produced by P01 projects, and to provide the genomics data """"""""context"""""""" for meaningful interpretation and analysis of this data;and 3) To apply innovative statistical methods for integrated analysis of JIA genomics data to facilitate the use of mechanistic insights in constructing predictive transcriptional signatures.

Public Health Relevance

The Informatics Core will provide comprehensive support for management, analysis and interpretation of gene expression data generated by each of the projects in this Program Project. The Informatics Core will also develop a JIA genomics data portal that will be an accessible resource for the research community, and the Core will use innovative methods of analyzing gene expression data to understand disease mechanisms in JIA and develop molecular tools for clinical use in predicting outcomes.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-HL)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cincinnati Children's Hospital Medical Center
United States
Zip Code
Hinks, Anne; Marion, Miranda C; Cobb, Joanna et al. (2018) Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis. Arthritis Rheumatol 70:957-962
Schulert, Grant S; Zhang, Mingce; Husami, Ammar et al. (2018) Brief Report: Novel UNC13D Intronic Variant Disrupting an NF-?B Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis. Arthritis Rheumatol 70:963-970
Gohar, Faekah; Anink, Janneke; Moncrieffe, Halima et al. (2018) S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. J Rheumatol 45:547-554
McIntosh, Laura A; Marion, Miranda C; Sudman, Marc et al. (2017) Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. Arthritis Rheumatol 69:2222-2232
Langefeld, Carl D; Ainsworth, Hannah C; Cunninghame Graham, Deborah S et al. (2017) Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 8:16021
Moncrieffe, Halima; Bennett, Mark F; Tsoras, Monica et al. (2017) Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology (Oxford) 56:1542-1551
Hinks, A; Bowes, J; Cobb, J et al. (2017) Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. Ann Rheum Dis 76:765-772
Ombrello, Michael J; Arthur, Victoria L; Remmers, Elaine F et al. (2017) Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Ann Rheum Dis 76:906-913
Schulert, Grant S; Fall, Ndate; Harley, John B et al. (2016) Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicroRNA-125a-5p in Polarized Monocyte Phenotypes. Arthritis Rheumatol 68:2300-13
Spreafico, Roberto; Rossetti, Maura; Whitaker, John W et al. (2016) Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4+ T cell activation pathways. Proc Natl Acad Sci U S A 113:13845-13850

Showing the most recent 10 out of 56 publications