Articular cartilage functions as a bearing surface in freely moving joints such as hip and knee. It provides a low friction surface with excellent wear characteristics, it helps to distribute joint contact loads over a larger area than would be present if there was bone-to-bone contact, and it performs these functions while loaded at several times body-weight. Tissue engineered cartilage must be able to perform the same mechanical functions as native tissue. The Biomechanics Core Facility will provide material testing and general biomechanical expertise for evaluation of tissue-engineered constructs. Material properties will be determined using widely accepted test methods and models. Functional aspects of the repair will be investigated using specialized tests. In addition to supporting PROJECTS I, II, and III, biomechanical investigations will benefit from imaging capabilities of the Morphology core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR053622-05
Application #
8380799
Study Section
Special Emphasis Panel (ZAR1-CHW-J)
Project Start
Project End
2014-04-30
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
5
Fiscal Year
2012
Total Cost
$78,584
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kean, Thomas J; Mera, Hisashi; Whitney, G Adam et al. (2016) Disparate response of articular- and auricular-derived chondrocytes to oxygen tension. Connect Tissue Res 57:319-33
Whitney, G A; Mansour, J M; Dennis, J E (2015) Coefficient of Friction Patterns Can Identify Damage in Native and Engineered Cartilage Subjected to Frictional-Shear Stress. Ann Biomed Eng 43:2056-68
Chung, Chen-Yuan; Mansour, Joseph M (2015) Determination of poroelastic properties of cartilage using constrained optimization coupled with finite element analysis. J Mech Behav Biomed Mater 42:10-8
Kean, Thomas J; Dennis, James E (2015) Synoviocyte Derived-Extracellular Matrix Enhances Human Articular Chondrocyte Proliferation and Maintains Re-Differentiation Capacity at Both Low and Atmospheric Oxygen Tensions. PLoS One 10:e0129961
Chung, Chen-Yuan; Heebner, Joseph; Baskaran, Harihara et al. (2015) Ultrasound Elastography for Estimation of Regional Strain of Multilayered Hydrogels and Tissue-Engineered Cartilage. Ann Biomed Eng 43:2991-3003
Correa, D; Somoza, R A; Lin, P et al. (2015) Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis Cartilage 23:443-53
Mansour, Joseph M; Gu, Di-Win Marine; Chung, Chen-Yuan et al. (2014) Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Ann Biomed Eng 42:2190-202
Song, In-Hwan; Dennis, James E (2014) Simple evaluation method for osteoinductive capacity of cells or scaffolds using ceramic cubes. Tissue Cell 46:372-8
Motavalli, Mostafa; Akkus, Ozan; Mansour, Joseph M (2014) Depth-dependent shear behavior of bovine articular cartilage: relationship to structure. J Anat 225:519-26
Somoza, Rodrigo A; Welter, Jean F; Correa, Diego et al. (2014) Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue Eng Part B Rev 20:596-608

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