P01 AT002034 (Frei) 09/30/03-05/31/08 NIH/NCCAM Center of Excellence for Research on Complementary and Alternative Medicine Antioxidant Therapies (CERCAT) The major goals of this program project grant are to determine the roles of oxidative and nitrative stress in animal models of atherosclerosis, Lou Gehrig's disease, and aging, and the protective effects of lipoic acid and metal chelation therapy. The major goals of Project 1 (Metal Chelators and Thiols in Endothelial Function and CVD) are to understand the mechanisms by which thiol compounds and transition metals affect redoxsensitive cellular signaling and transcription factor activation;and to investigate in animal models of inflammation and atherosclerosis whether lipoic acid and metal chelators exert anti-inflammatory and antiatherosclerotic effects by inhibiting cellular adhesion molecule expression. Roles: Program Director, Project 1 Leader (Metal Chelators and Thiols in Endothelial Function and CVD), and Administrative Core Director

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program Projects (P01)
Project #
5P01AT002034-10
Application #
8377896
Study Section
Special Emphasis Panel (ZAT1-SM)
Project Start
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
10
Fiscal Year
2012
Total Cost
$454,454
Indirect Cost
$170,419
Name
Oregon State University
Department
Type
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
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Williams, Jared R; Trias, Emiliano; Beilby, Pamela R et al. (2016) Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD. Neurobiol Dis 89:1-9
Zhang, Wei-Jian; Frei, Balz (2015) Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice. Mediators Inflamm 2015:274314
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Wei, Hao; Zhang, Wei-Jian; Leboeuf, Renee et al. (2014) Copper induces--and copper chelation by tetrathiomolybdate inhibits--endothelial activation in vitro. Redox Rep 19:40-8
Keith, Dove; Finlay, Liam; Butler, Judy et al. (2014) Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. Biochem Biophys Res Commun 450:324-9
Viera, Liliana; Radmilovich, Milka; Vargas, Marcelo R et al. (2013) Temporal patterns of tyrosine nitration in embryo heart development. Free Radic Biol Med 55:101-8
Rhoads, Timothy W; Williams, Jared R; Lopez, Nathan I et al. (2013) Using theoretical protein isotopic distributions to parse small-mass-difference post-translational modifications via mass spectrometry. J Am Soc Mass Spectrom 24:115-24
Gandelman, Mandi; Levy, Mark; Cassina, Patricia et al. (2013) P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway. J Neurochem 126:382-8
Franco, Maria Clara; Ye, Yaozu; Refakis, Christian A et al. (2013) Nitration of Hsp90 induces cell death. Proc Natl Acad Sci U S A 110:E1102-11

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