The Protein Chemistry Core Component is dedicated to collaborative projects with members of this Program Project involving the structural analysis of proteins. The projects are derived from all of the research components in the Program and address problems in regulation of DNA synthesis, of programmed cell death or apoptosis, of mRNA processing, and of transcription as they relate to the oncognic transformation of cells. These projects fall into four categories: (I) proteins involved in DNA synthesis and chromatin assembly, (ii) proteins involved in apoptosis, (iii) proteins involved in mRNA splicing, and (iv) proteins involved in transcriptional control of viral and cellular genes. The methodologies involved in these investigations involve three areas: protein sequencing, analysis of protein modification, and peptide synthesis. The Core Component serves four specific function: 1. Determination of peptide sequences of purified proteins for isolation and identification of specific cDNA and genes. 2. Analysis of post-translational modifications. 3. Synthesis of peptides for functional studies and for immunizations. 4. Optimization of sensitive methods in protein chemistry.
| Tramentozzi, Elisa; Ferraro, Paola; Hossain, Manzar et al. (2018) The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592. Cell Cycle 17:1102-1114 |
| Arun, Gayatri; Diermeier, Sarah D; Spector, David L (2018) Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol Med 24:257-277 |
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| Huang, Yu-Han; Klingbeil, Olaf; He, Xue-Yan et al. (2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev 32:915-928 |
| Livshits, Geulah; Alonso-Curbelo, Direna; Morris 4th, John P et al. (2018) Arid1a restrains Kras-dependent changes in acinar cell identity. Elife 7: |
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| Bhagwat, Anand S; Lu, Bin; Vakoc, Christopher R (2018) Enhancer dysfunction in leukemia. Blood 131:1795-1804 |
| Banito, Ana; Li, Xiang; Laporte, Aimée N et al. (2018) The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell 34:346-348 |
| Skucha, Anna; Ebner, Jessica; Schmöllerl, Johannes et al. (2018) MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun 9:1983 |
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