This core provides centralized services to the program project in three related areas: biostatistics, research computing, and data collection. The biostatisticians collaborate in all phases of research from study design, through interim analysis and monitoring, to final analysis and manuscript preparation. Biostatisticians were co-authors on over 130 manuscripts during the previous funding period, and are integral parts of the protocol development and review process. The computing group is responsible for the maintenance and operation of shared computing systems. These include a cluster of Alpha machines that support a centralized patient database, known as Gateway, and a Sun workstation that supports statistical computing. The computing staff create and maintain entry and reporting programs for Gateway, assist others in data extraction from the database, and maintain electronic connections to laboratory information which is downloaded directly to Gateway. The data collection group is responsible for data abstraction and entry into Gateway, and for maintenance of archival research files, which are stored in a web-accessible optical image library (OWL). The staff follow an explicit protocol for data abstraction, coding, key entry, and quality control that is applied uniformly to all transplant recipients entering research protocols of the Clinical Research Division, of whom a significant number enter protocols supported by this program project.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA018029-37A1
Application #
8368296
Study Section
Special Emphasis Panel (ZCA1-GRB-T (M1))
Project Start
1997-12-22
Project End
2017-06-30
Budget Start
2012-09-25
Budget End
2013-06-30
Support Year
37
Fiscal Year
2012
Total Cost
$367,182
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Oda, Shannon K; Daman, Andrew W; Garcia, Nicolas M et al. (2017) A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia. Blood 130:2410-2419
Lee, Stephanie J; Nguyen, Tam D; Onstad, Lynn et al. (2017) Success of Immunosuppressive Treatments in Patients with Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant :
Schmitt, Thomas M; Aggen, David H; Ishida-Tsubota, Kumiko et al. (2017) Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro. Nat Biotechnol 35:1188-1195
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Hill, Joshua A; Mayer, Bryan T; Xie, Hu et al. (2017) The cumulative burden of double-stranded DNA virus detection after allogeneic HCT is associated with increased mortality. Blood 129:2316-2325
Inamoto, Yoshihiro; Lee, Stephanie J (2017) Late effects of blood and marrow transplantation. Haematologica 102:614-625
Stromnes, Ingunn M; Hulbert, Ayaka; Pierce, Robert H et al. (2017) T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma. Cancer Immunol Res 5:978-991
Shadman, Mazyar; Hingorani, Sangeeta; Lanum, Scott A et al. (2017) Allogeneic hematopoietic cell transplant for patients with end stage renal disease requiring dialysis - a single institution experience. Leuk Lymphoma 58:740-742
Sala Torra, Olga; Othus, Megan; Williamson, David W et al. (2017) Next-Generation Sequencing in Adult B Cell Acute Lymphoblastic Leukemia Patients. Biol Blood Marrow Transplant 23:691-696
Fisher, Cynthia E; Hohl, Tobias M; Fan, Wenhong et al. (2017) Validation of single nucleotide polymorphisms in invasive aspergillosis following hematopoietic cell transplantation. Blood 129:2693-2701

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