The Biomarkers Core will serve as a collection and distribution point for blood and tissue samples related to Projects I, II, III, and IV as well as Core D. It will provide a resource and service for carrying out the laboratory analyses proposed in this application in support of the basic science and clinical trials. The Core will develop and be responsible for the appropriate sample collection, logging, tracking, storage, sample preparation procedures, sample processing, and distribution for all animal and human samples collected during the course of this proposal. It also will be responsible for the training of personnel involved in the collection and processing of study samples. In addition, the Core will be responsible for developing immunohistochemical and analytical methods for the measurement of targets from Projects I, II, III, and IV. The Biomarkers Core will perform assays and will work closely with the Biometry Core to provide data for reporting and interpretation. Quality assurance and quality control procedures will continue to be developed by the Biomarkers Core for sample acquisition, processing, and analysis procedures included in the proposal. The Biomarkers Core will develop and optimize methods for measuring the secondary laboratory-directed research endpoints proposed in each project. Endpoints to be analyzed by the Biomarkers Core include blood and skin levels of chemoprevention agents and micronutrients, histopathology and karyometric measurements on skin biopsies as well as immunohistochemical assays for cell proliferation, apoptosis, p53 protein expression, retinoid receptors, and other targets identified within the proposal.
| Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278 |
| Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305 |
| Roh, Eunmiri; Lee, Mee-Hyun; Zykova, Tatyana A et al. (2018) Targeting PRPK and TOPK for skin cancer prevention and therapy. Oncogene 37:5633-5647 |
| Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931 |
| Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332 |
| Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82 |
| Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1: |
| Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854 |
| Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6 |
| Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919 |
Showing the most recent 10 out of 395 publications
