The goal of the Chemoprevention of Skin Cancer (CSC) Biometry Core is to collaborate with all investigators in development and application of statistical methocis for design, conduct and analysis of all projects, including data management and computing support, This goal is achieved through the following specific aims: 1, To provide statistical and epidemiological collaboration in the design and execution of all projects. 2, To develop procedures for data collection, and build and maintain computer databases for information storage and retrieval. 3, To provide interim reports on individual study progress. 4, To provide statistical analysis and participate in writing manuscripts for publication. 5, To provide an administrative link between Core D and Project 3 in terms of managing and accounting for study agents. Biometry support is required in all phases of program studies, At the design phase, the core staff addresses statistical design, analysis methocis, power and sample size issues, and works with other investigators to establish data management and quality control procedures. They then participate in the management, oversight and interim reporting of ongoing studies. Upon study completion, core personnel perform statistical analyses in collaboration with other investigators and participate in preparation of manuscripts for publication. As a unique expertise, the core provides support in the design and analysis of studies involving karyometric endpoints. The Biometry Core continues to be used by all investigators in both clinical and laboratory settings. This highly interactive and clinically translational research program project focuses on the successful preclinical testing of targeted chemoprevention agents in innovative mouse models (Projects 1 and 2) followed by the design and implementation of clinical trials in at risk human populations (Project 3). Detailed descriptions ofthe decision-tree selection process as well as the interactions between Projects and Cores are found on the Resources Format Page.

Public Health Relevance

The Biometry Core interacts with all CSCPP investigators to insure that their scientific questions are addressed through stringent research design and appropriate statistical methods, resulting in valid and reliable results suitable for dissemination and publication.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA027502-30
Application #
8504922
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
30
Fiscal Year
2013
Total Cost
$180,361
Indirect Cost
$59,648
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Dickinson, Sally E; Janda, Jaroslav; Criswell, Jane et al. (2016) Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin. Cancer Prev Res (Phila) 9:215-24
Peng, C; Zeng, W; Su, J et al. (2016) Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. Oncogene 35:1170-9
Janda, Jaroslav; Burkett, Nichole B; Blohm-Mangone, Karen et al. (2016) Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem Photobiol 92:816-825
Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-9
Kim, J-E; Roh, E; Lee, M H et al. (2016) Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis. Oncogene 35:4091-101
Jeter, Joanne M; Curiel-Lewandrowski, Clara; Stratton, Steven P et al. (2016) Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm. Cancer Prev Res (Phila) 9:128-34
Franklin, Stephen J; Myrdal, Paul B (2015) Solid-State and Solution Characterization of Myricetin. AAPS PharmSciTech 16:1400-8
Curiel-Lewandrowski, Clara; Tang, Jean Y; Einspahr, Janine G et al. (2015) Pilot study on the bioactivity of vitamin d in the skin after oral supplementation. Cancer Prev Res (Phila) 8:563-9
Kim, Jong-Eun; Son, Joe Eun; Jeong, Hyein et al. (2015) A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer. Cancer Res 75:2716-28
Bermudez, Yira; Stratton, Steven P; Curiel-Lewandrowski, Clara et al. (2015) Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin. Cancer Prev Res (Phila) 8:720-8

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