The goal of the Chemoprevention of Skin Cancer (CSC) Biometry Core is to collaborate with all investigators in development and application of statistical methocis for design, conduct and analysis of all projects, including data management and computing support, This goal is achieved through the following specific aims: 1, To provide statistical and epidemiological collaboration in the design and execution of all projects. 2, To develop procedures for data collection, and build and maintain computer databases for information storage and retrieval. 3, To provide interim reports on individual study progress. 4, To provide statistical analysis and participate in writing manuscripts for publication. 5, To provide an administrative link between Core D and Project 3 in terms of managing and accounting for study agents. Biometry support is required in all phases of program studies, At the design phase, the core staff addresses statistical design, analysis methocis, power and sample size issues, and works with other investigators to establish data management and quality control procedures. They then participate in the management, oversight and interim reporting of ongoing studies. Upon study completion, core personnel perform statistical analyses in collaboration with other investigators and participate in preparation of manuscripts for publication. As a unique expertise, the core provides support in the design and analysis of studies involving karyometric endpoints. The Biometry Core continues to be used by all investigators in both clinical and laboratory settings. This highly interactive and clinically translational research program project focuses on the successful preclinical testing of targeted chemoprevention agents in innovative mouse models (Projects 1 and 2) followed by the design and implementation of clinical trials in at risk human populations (Project 3). Detailed descriptions ofthe decision-tree selection process as well as the interactions between Projects and Cores are found on the Resources Format Page.
The Biometry Core interacts with all CSCPP investigators to insure that their scientific questions are addressed through stringent research design and appropriate statistical methods, resulting in valid and reliable results suitable for dissemination and publication.
|Dickinson, Sally E; Rusche, Jadrian J; Bec, Sergiu L et al. (2015) The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog 54:1513-20|
|Glazer, Evan S; Hornbrook, Mark C; Krouse, Robert S (2014) A meta-analysis of randomized trials: immediate stent placement vs. surgical bypass in the palliative management of malignant biliary obstruction. J Pain Symptom Manage 47:307-14|
|Williams, Joshua D; Bermudez, Yira; Park, Sophia L et al. (2014) Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue. J Photochem Photobiol B 132:56-65|
|Sheng, Yuqiao; Li, Wei; Zhu, Feng et al. (2014) 3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer. J Biol Chem 289:28192-201|
|Lim, Tae-Gyu; Lee, Sung-Young; Huang, Zunnan et al. (2014) Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prev Res (Phila) 7:466-74|
|Wen, W; Peng, C; Kim, M O et al. (2014) Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene 33:421-8|
|Lim, Do Young; Lee, Mee-Hyun; Shin, Seung Ho et al. (2014) (+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38. Cancer Prev Res (Phila) 7:856-65|
|Yao, Ke; Chen, Hanyong; Liu, Kangdong et al. (2014) Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer Prev Res (Phila) 7:958-67|
|Dickinson, Sally E; Olson, Erik R; Levenson, Corey et al. (2014) A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes. Arch Biochem Biophys 558:143-52|
|Franklin, Stephen J; Dickinson, Sally E; Karlage, Kelly L et al. (2014) Stability of sulforaphane for topical formulation. Drug Dev Ind Pharm 40:494-502|
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