The objectives of the Administrative and Statistical Core are to continue to provide overall administrative direction and statistical support for all aspects ofthe PPG Program. The services will include the following: 1. To assist in the biostatistical design of experiments in all of the projects with respect to sample size and potential differences between groups 2. To assist in the biostatistical analysis of laboratory data, particulariy where large amounts of information are generated (e.g. proteomics data) 3. To facilitate optimal interactions among all projects and cores 4. To coordinate meetings and communication among the Executive Committee members 5. To coordinate and facilitate the input of members ofthe Scientific Advisory Board, including meetings and travel arrangements 6. To provide administrative support to the investigators, including secretarial, personnel management, and document generation 7. To provide support and administration for appropriate centralized data sharing for the proposed projects, including document generation and organization and documentation of requests. 8. To manage all financial aspects of the grant 9. To work with internal and external institutions and agencies to ensure appropriate administrative documentation, communication, and accountability

Public Health Relevance

Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GVHD. Strategies that mitigate GVHD will allow for better harnessing of this effective therapeutic modality to treat many patients with hematological cancers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
7P01CA039542-27
Application #
8725947
Study Section
Special Emphasis Panel (ZCA1-RPRB-J)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
27
Fiscal Year
2014
Total Cost
$96,038
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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Levine, John E; Braun, Thomas M; Harris, Andrew C et al. (2015) A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study. Lancet Haematol 2:e21-9
Tkachev, Victor; Goodell, Stefanie; Opipari, Anthony W et al. (2015) Programmed death-1 controls T cell survival by regulating oxidative metabolism. J Immunol 194:5789-800
Levine, John E; Hogan, William J; Harris, Andrew C et al. (2014) Improved accuracy of acute graft-versus-host disease staging among multiple centers. Best Pract Res Clin Haematol 27:283-7

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