Shared resource Core A will provide all administrative support to the grant. The core, also provides clinical data management and all statistical support to the research projects and other shared resource cores. Specific areas of administrative responsibility include long and short term planning, review of scientific progress and coordination of the interactions between the shared resource cores and the research projects. Toward these ends, both overall co-Program Directors will participate in this Core. Also, both internal and external scientific advisory committees will be formed to provide independent, expert, program evaluation. Purchasing and personnel management, budget and accounts management, and the preparation and submission of progress reports will also be coordinated by this administrative core. Statistical support provided by this core includes statistical design, control, and analyses of the clinical studies in Projects 1 and 2, and statistical design and analyses of the many different experiments and studies in the other projects and cores.

Public Health Relevance

The entire program project effort benefits from the integrated support provided by this core. Administrative and financial organization and supervision are crucial in making possible high quality, productive research, and this core provides this necessary support. Statistical support, trial design, data management and protocol review are essential to the success of the grant's research efforts.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA059827-16A1
Application #
8609644
Study Section
Special Emphasis Panel (ZCA1-RPRB-C (O1))
Project Start
1997-02-01
Project End
2019-04-30
Budget Start
2014-05-15
Budget End
2015-04-30
Support Year
16
Fiscal Year
2014
Total Cost
$422,849
Indirect Cost
$148,803
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Hunter, Klaudia U; Lee, Oliver E; Lyden, Teresa H et al. (2014) Aspiration pneumonia after chemo-intensity-modulated radiation therapy of oropharyngeal carcinoma and its clinical and dysphagia-related predictors. Head Neck 36:120-5
Vainshtein, Jeffrey M; Spector, Matthew E; McHugh, Jonathan B et al. (2014) Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:513-9
Nazem-Zadeh, Mohammad-Reza; Chapman, Christopher H; Chenevert, Thomas et al. (2014) Response-driven imaging biomarkers for predicting radiation necrosis of the brain. Phys Med Biol 59:2535-47
Stenmark, Matthew H; Cao, Yue; Wang, Hesheng et al. (2014) Estimating functional liver reserve following hepatic irradiation: adaptive normal tissue response models. Radiother Oncol 111:418-23
Hunter, Klaudia U; Schipper, Matthew; Feng, Felix Y et al. (2013) Toxicities affecting quality of life after chemo-IMRT of oropharyngeal cancer: prospective study of patient-reported, observer-rated, and objective outcomes. Int J Radiat Oncol Biol Phys 85:935-40
Wilkie, Joel R; Matuszak, Martha M; Feng, Mary et al. (2013) Use of plan quality degradation to evaluate tradeoffs in delivery efficiency and clinical plan metrics arising from IMRT optimizer and sequencer compromises. Med Phys 40:071708
Vainshtein, Jeffrey; Eisbruch, Avraham (2013) Function, muscles, and sparing by IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 85:577-8
Cao, Yue; Wang, Hesheng; Johnson, Timothy D et al. (2013) Prediction of liver function by using magnetic resonance-based portal venous perfusion imaging. Int J Radiat Oncol Biol Phys 85:258-63
Hunter, Klaudia U; Fernandes, Laura L; Vineberg, Karen A et al. (2013) Parotid glands dose-effect relationships based on their actually delivered doses: implications for adaptive replanning in radiation therapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys 87:676-82
Farjam, Reza; Parmar, Hemant A; Noll, Douglas C et al. (2012) An approach for computer-aided detection of brain metastases in post-Gd T1-W MRI. Magn Reson Imaging 30:824-36

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