This Core component is intended to provide administrative and fiscal oversight to the operations ofthe 4 individual Research Projects and the Scientific Core Component. There are 3 specific aims: 1. Promote integration of individual scientific projects in the context of the Program themes. 2. Coordinate review of scientific activities by internal and external advisory groups. 3. Provide administrative support in the form of fiscal oversight for Program-related expenditures in individual projects and in the scientific core (cores B), coordination of program related services provided by the Core, and responsibility for the preparation of progress reports and continuation applications on an annual basis. These goals will be accomplished through the activities ofthe administrative unit (Dr. Stark and Ms. Lannum) and the internal and external advisory groups.

Public Health Relevance

This activity serves to organize interproject communication and management and as the interface between the Program Project and the NCI.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-RPRB-0)
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Cleveland Clinic Lerner
United States
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Dermawan, Josephine Kam Tai; Hitomi, Masahiro; Silver, Daniel J et al. (2016) Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models. Cancer Res 76:2432-42
Zhou, Hao; Yu, Minjia; Zhao, Junjie et al. (2016) IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease. Hepatology 64:1978-1993
Wang, Xin; Majumdar, Tanmay; Kessler, Patricia et al. (2016) STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection. Cell Host Microbe 20:329-41
Chattopadhyay, Saurabh; Kuzmanovic, Teodora; Zhang, Ying et al. (2016) Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis. Immunity 44:1151-61
White, Christine L; Kessler, Patricia M; Dickerman, Benjamin K et al. (2016) Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members. J Biol Chem 291:13535-45
Lu, Tao; Stark, George R (2015) Using sequential immunoprecipitation and mass spectrometry to identify methylation of NF-κB. Methods Mol Biol 1280:383-93
Lu, Tao; Stark, George R (2015) NF-κB: Regulation by Methylation. Cancer Res 75:3692-5
Dasgupta, Maupali; Dermawan, Josephine Kam Tai; Willard, Belinda et al. (2015) STAT3-driven transcription depends upon the dimethylation of K49 by EZH2. Proc Natl Acad Sci U S A 112:3985-90
Zhao, Junjie; Bulek, Katarzyna; Gulen, Muhammet F et al. (2015) Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice. Gastroenterology 149:1860-1871.e8
De, Sarmishtha; Zhou, Hao; DeSantis, David et al. (2015) Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal. Proc Natl Acad Sci U S A 112:9680-5

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