Cervical cancer is the leading cause of cancer mortality among women in developing countries;in the developed world, extensive health care resources are used to screen and diagnose for cervical cancer and its precursors. The overall goal of this program project is to develop new optical technologies and molecular imaging agents that increase accuracy, decrease costs, and reduce the need for provider expertise and infrastructure in both the developed and developing worlds. The goal of the Administration, Epidemiology, and Research Protocol Management Core (Core A)is to coordinate the overall project and core organization, and ensure continued adherence to goals. As demonstrated throughout this Program Project, all projects and cores have made significant progress toward their original aims. Well-coordinated meetings of the entire team have proven critical in this process. Core A will continue to facilitate these productive interactions, as well as to coordinate submission of publications to peer-reviewed journals, trips to scientific meetings, and submission of reports to the NCI and the Institutional Review Boards at all clinical trial locations. In the last five years, Core A has coordinated the submission of 84 manuscripts, prepared numerous abstracts, and increased exposure for all project and core leaders. All previous core leaders have become project leaders in this renewal. New core leaders have been added. Two remarkable events have broadened the scope of the Program Project: 1) a Biomedical Research Partnership (BRP) grant, and 2) foundation support from ExxonMobil to begin a cervical screening program in Nigeria. The BRP is inventing new technologies and molecular imaging agents that can be spun out into the P01. The ExxonMobil foundation funding has allowed us to begin a meaningful and rich collaboration with the University College Hospital in Ibadan and coordinated five additional screening sites that are representative of the ethnic, religious, and political diversity of Nigeria.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-RPRB-7 (O1))
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Drexel University
United States
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Nghiem, Van T; Davies, Kalatu R; Beck, J Robert et al. (2016) Overtreatment and Cost-Effectiveness of the See-and-Treat Strategy for Managing Cervical Precancer. Cancer Epidemiol Biomarkers Prev 25:807-14
Nghiem, Van T; Davies, Kalatu R; Chan, Wenyaw et al. (2016) Disparities in cervical cancer survival among Asian-American women. Ann Epidemiol 26:28-35
Yamal, Jose-Miguel; Guillaud, Martial; Atkinson, E Neely et al. (2015) Prediction using hierarchical data: Applications for automated detection of cervical cancer. Stat Anal Data Min 8:65-74
Montealegre, Jane R; Landgren, Rachel M; Anderson, Matthew L et al. (2015) Acceptability of self-sample human papillomavirus testing among medically underserved women visiting the emergency department. Gynecol Oncol 138:317-22
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Li, Gerald; van Niekerk, Dirk; Miller, Dianne et al. (2014) Molecular fixative enables expression microarray analysis of microdissected clinical cervical specimens. Exp Mol Pathol 96:168-77
Wang, Lu; Lee, Jong Soo; Lane, Pierre et al. (2014) A statistical model for removing inter-device differences in spectroscopy. Opt Express 22:7617-24
Scheurer, Michael E; Danysh, Heather E; Follen, Michele et al. (2014) Association of traffic-related hazardous air pollutants and cervical dysplasia in an urban multiethnic population: a cross-sectional study. Environ Health 13:52

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