The goal of Core D Is to provide the leadership, administrative oversight as well as statistical analysis and related quality control to insure the completion of the specific aims of Projects 1 through 4, as well as the successful continuance of the Nurses'Health Study cohort.
The specific aims are as follows: 1. To provide overall leadership to the Program Project and the Nurses'Health Study. 2. To provide administrative oversight for the Program Project. 3. To provide statistical expertise and programming support to insure the completion of Project 1-4 aims. 4. To maintain and further develop quality control measures related to data analysis and documentation. 5. To support and facilitate use of Nurses'Health Study resources by collaborating scientists. In Core D, we provide the structure and resources to facilitate continued communication between all Cores and Projects, as well as all investigators working with the cohort. The Core coordinates the regular bi-weekly meeting of NHS investigators as well as the annual meeting of the External Advisory Committee. All Program Project-related IRB activities are conducted through this core. We also provide a framework for data analyses as well as specific biostatistical support for Projects 1-4;computer programming is provided under the direction of study biostatisticians and project investigators. In addition, the Core provides an ongoing program of quality control and data documentation that are necessary to help insure that all users of the NHS data base are knowledgeable and aware of both its strengths and limitations, and publications are accurate and error free. Finally, by providing support for all initial queries from potential collaborators as well as data documentation, the Core facilitates the use of the Nurses'Health Study research platform for a range of scientific collaborations.

Public Health Relevance

This Core provides a broad array of administrative, data management and biostatistical services as well as overall leadership to insure the smooth operation and optimal productivity of the Program Project, as well as the Nurses'Health Study as a whole. Hence this Core is essential to our overall mission of finding ways to reduce risk of breast, colorectal and ovarian cancers and improve survival in women with these cancers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-7 (O1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Rice, Megan S; Rosner, Bernard A; Tamimi, Rulla M (2017) Percent mammographic density prediction: development of a model in the nurses' health studies. Cancer Causes Control 28:677-684
Hanyuda, Akiko; Cao, Yin; Hamada, Tsuyoshi et al. (2017) Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. Eur J Epidemiol 32:393-407
Irshad, Humayun; Oh, Eun-Yeong; Schmolze, Daniel et al. (2017) Crowdsourcing scoring of immunohistochemistry images: Evaluating Performance of the Crowd and an Automated Computational Method. Sci Rep 7:43286
Jiménez, M C (2017) Response to comment on plasma uric acid and risk of ischaemic stroke in women. Eur J Neurol 24:e2
Wang, Tiange; Huang, Tao; Heianza, Yoriko et al. (2017) Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain. Diabetes 66:2704-2712
Rice, Megan S; Tworoger, Shelley S; Hankinson, Susan E et al. (2017) Breast cancer risk prediction: an update to the Rosner-Colditz breast cancer incidence model. Breast Cancer Res Treat 166:227-240
Nimptsch, Katharina; Song, Mingyang; Aleksandrova, Krasimira et al. (2017) Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies. Eur J Epidemiol 32:419-430
Masugi, Yohei; Nishihara, Reiko; Hamada, Tsuyoshi et al. (2017) Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer. Cancer Immunol Res 5:1046-1055
Linos, E; Li, W Q; Han, J et al. (2017) Lifetime ultraviolet radiation exposure and lentigo maligna melanoma. Br J Dermatol 176:1666-1668
Tworoger, Shelley S; Doherty, Jennifer Anne (2017) Epidemiologic paradigms for progress in ovarian cancer research. Cancer Causes Control 28:361-364

Showing the most recent 10 out of 1577 publications