The goal of Core D Is to provide the leadership, administrative oversight as well as statistical analysis and related quality control to insure the completion of the specific aims of Projects 1 through 4, as well as the successful continuance of the Nurses'Health Study cohort.
The specific aims are as follows: 1. To provide overall leadership to the Program Project and the Nurses'Health Study. 2. To provide administrative oversight for the Program Project. 3. To provide statistical expertise and programming support to insure the completion of Project 1-4 aims. 4. To maintain and further develop quality control measures related to data analysis and documentation. 5. To support and facilitate use of Nurses'Health Study resources by collaborating scientists. In Core D, we provide the structure and resources to facilitate continued communication between all Cores and Projects, as well as all investigators working with the cohort. The Core coordinates the regular bi-weekly meeting of NHS investigators as well as the annual meeting of the External Advisory Committee. All Program Project-related IRB activities are conducted through this core. We also provide a framework for data analyses as well as specific biostatistical support for Projects 1-4;computer programming is provided under the direction of study biostatisticians and project investigators. In addition, the Core provides an ongoing program of quality control and data documentation that are necessary to help insure that all users of the NHS data base are knowledgeable and aware of both its strengths and limitations, and publications are accurate and error free. Finally, by providing support for all initial queries from potential collaborators as well as data documentation, the Core facilitates the use of the Nurses'Health Study research platform for a range of scientific collaborations.

Public Health Relevance

This Core provides a broad array of administrative, data management and biostatistical services as well as overall leadership to insure the smooth operation and optimal productivity of the Program Project, as well as the Nurses'Health Study as a whole. Hence this Core is essential to our overall mission of finding ways to reduce risk of breast, colorectal and ovarian cancers and improve survival in women with these cancers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-RPRB-7 (O1))
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Brigham and Women's Hospital
United States
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Yuan, Chen; Clish, Clary B; Wu, Chen et al. (2016) Circulating Metabolites and Survival Among Patients With Pancreatic Cancer. J Natl Cancer Inst 108:djv409
Li, W-Q; Han, J; Cho, E et al. (2016) Personal history of psoriasis and risk of incident cancer among women: a population-based cohort study. Br J Dermatol 174:1108-11
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Li, Wen-Qing; Gao, Xiang; Tworoger, Shelley S et al. (2016) Natural hair color and questionnaire-reported pain among women in the United States. Pigment Cell Melanoma Res 29:239-42

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