Core A: The Physics Core is responsible for providing and maintaining PDT laser sources, for in vivo and ex vivo light dosimetry, for quality assurance of light delivery systems, and for establishment of absolute light dosimetry standards traceable to NIST. It implements useful technologies to routine clinical application. The Physics Core is responsible for providing laser support and in vivo light dosimetry for all projects. It works with Project 1 to develop human clinical trials for treatment of pleural disease. The core supports maintenance and operation of the lasers housed in the 8th floor of the Smilow Center for Translational Research (SCTR 8W) that will be used for the cell and mouse PDT experiments included in Projects 2, 3 and 4. All of these illuminations will be performed through the services of the Animal/Pathology Core with assistance from the Physics Core as needed. In addition, the Physics Core will perform an annual on-site visit for dosimetry calibration at Roswell Park Cancer Institute (RPCI) and will remotely perform quarterly reviews of the light dosimetry data from RPCI via email submission. The Physics Core will develop techniques to improve PDT dosimetry for human clinical trials to achieve better uniformity of light fluence distribution. Determination of tissue optical properties, blood flow, sensitizer distribution, and tissue oxygenation for individual patients may prove to be important in providing individualized treatment planning and thus improving cancer treatment. The major components of the Physics Core can be summarized as follows: 1) to provide maintenance and operation of laser and light sources for PDT;2) performance of in vivo and ex vivo light dosimetry;3) measurement of absolute light dosimetry;4) support for light dosimetry at RPCI and 5) to perform explicit PDT dosimetry for tissue optical properties, drug concentration, and tissue oxygenation before, during, and after PDT.

Public Health Relevance

Core A PDT dosimetry of light and drug concentration is critical for the pleural PDT clinical trials to be performed in the proposal. QA of the light delivery system, laser power standard, and dosimetry measurement equipment is essential for consistent outcome of PDT clinical trials.

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National Cancer Institute (NCI)
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Kim, Michele M; Ghogare, Ashwini A; Greer, Alexander et al. (2017) On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling. Phys Med Biol 62:R1-R48
Friedberg, Joseph S; Simone 2nd, Charles B; Culligan, Melissa J et al. (2017) Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years. Ann Thorac Surg 103:912-919
Penjweini, Rozhin; Kim, Michele M; Zhu, Timothy C (2017) Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy. Med Phys 44:3767-3775
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Gemmell, Nathan R; McCarthy, Aongus; Kim, Michele M et al. (2017) A compact fiber-optic probe-based singlet oxygen luminescence detection system. J Biophotonics 10:320-326
Kim, Michele M; Penjweini, Rozhin; Zhu, Timothy C (2017) Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy. J Biomed Opt 22:28002

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