An Administrative Core, Core A, is in operation which will continue to be responsible for the overall scientific guidance and for providing seamless day-to-day management and organization. Specifically, the Administrative Core provides: (1) The Steering Committee, chaired by the PI and composed of the projectand core leaders, that meets monthly. This steering committee has been in charge of assessing progress and enhancing interactions among the projects. Also, this committee will oversee the appropriate functions of the Cores. This committee is responsible for making decisions on fiscal issues as well (e.g. re-allocation of funds) through consensus. (2) The Program Group composed of the PI, the project leaders and co- PI's of each of the projects, postdoctoral fellows and students, the director of the Lipidomics Core and Associate Directors, and the Director of the SL Animal Core. This scientific group already meets at least once a month (every third Thursday at noon for 2 hours) and will continue to do so. In these meetings the Program Group reviews progress by one of the projects and/or one of the cores. This group functions primarily to enhance the overall as well as specific scientific activities. In addition, review of key publications is undertaken in the form of a journal club. This group also discusses specific scientific and technical issues pertinent to the development of the projects and the overall program. (3) The Internal Advisory Committee. This committee has been most helpful in provide programmatic advice. This committee convenes at least twice a year for overall review and to offer advice on the future development of the program project at a scientific level. This group also helps advise and steer administrative issues within SBU. (4) The External Advisory Committee. This committee, composed of highly regarded scientists, has met once a year during the annual retreat of the Program Project, and it will continue to do so. It oversees the progress of the projects, the use of the Cores, and has been most helpful in discussions about strategy as well as most recently in discussions and recommendations on translational research. (5) Supervise the secretarial and business support of the program. The administrative manager will oversee the specific budgets of each projects and the cores, and will keep project leaders up to date on expenses versus budgets.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-J (M1))
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State University New York Stony Brook
Stony Brook
United States
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Chen, Jennifer Y; Newcomb, Benjamin; Zhou, Chan et al. (2017) Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep 7:44867
Janecke, Andreas R; Xu, Ruijuan; Steichen-Gersdorf, Elisabeth et al. (2017) Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. Hum Mutat 38:365-372
Xu, Ruijuan; Garcia-Barros, Monica; Wen, Sally et al. (2017) Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ :
Espaillat, Mel Pilar; Kew, Richard R; Obeid, Lina M (2017) Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis. Adv Biol Regul 63:140-155
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Pulkoski-Gross, Michael J; Uys, Joachim D; Orr-Gandy, K Alexa et al. (2017) Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat 130:47-56
Coant, Nicolas; Sakamoto, Wataru; Mao, Cungui et al. (2017) Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul 63:122-131
Hernández-Corbacho, María José; Salama, Mohamed F; Canals, Daniel et al. (2017) Sphingolipids in mitochondria. Biochim Biophys Acta 1862:56-68
Bai, Aiping; Mao, Cungui; Jenkins, Russell W et al. (2017) Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. PLoS One 12:e0177805
Lin, Chih-Li; Xu, Ruijuan; Yi, Jae Kyo et al. (2017) Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports 9:1488-1500

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