The Administrative (AD) Core of the proposed Program on the Processing of Complex Lesions in the Mammalian Genome will be responsible for coordinating administrative aspects of the program, and for facilitating interactions among the investigators. The primary goal of the AD Core will be to ensure the successful outcome of the Program by maintaining its focus and coherence, and continually monitoring its progress. Management of the Program will be carried out by the Director and co-Director with the assistance of an Executive Committee composed of the Project Leaders, and an External Advisory Board. In addition to monitoring and facilitating the scientific progress of the Program, the AD Core will also be responsible for overseeing the financial aspects of the Program, and for compliance with NIH and Institutional regulations.

Public Health Relevance

This Project is part of a multicomponent Program Project with the theme of understanding the processing of complex DNA damage by mammalian cells. The significance to human health is to generate new knowledge and paradigms for modeling DNA repair of DNA interstrand crosslinks (ICLs), to improve therapy using inducing compounds, and to identify new therapeutic targets for cancer treatment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA097175-10
Application #
8606191
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
10
Fiscal Year
2014
Total Cost
$27,451
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
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Smith, Stephanie; Fox, Jennifer; Mejia, Marco et al. (2014) Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. PLoS One 9:e87203
Wood, Richard D; Lange, Sabine S (2014) Breakthrough for a DNA break-preventer. Proc Natl Acad Sci U S A 111:2864-5
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Yousefzadeh, Matthew J; Wood, Richard D (2013) DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair (Amst) 12:1-9
Wang, Yucai; Han, Xiao; Wu, Fangming et al. (2013) Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res 23:1215-28
Bacolla, Albino; Temiz, Nuri A; Yi, Ming et al. (2013) Guanine holes are prominent targets for mutation in cancer and inherited disease. PLoS Genet 9:e1003816
Huang, Yaling; Li, Lei (2013) DNA crosslinking damage and cancer - a tale of friend and foe. Transl Cancer Res 2:144-154
Wang, Yucai; Leung, Justin W; Jiang, Yingjun et al. (2013) FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell 49:997-1009
Leung, Justin Wai Chung; Wang, Yucai; Fong, Ka Wing et al. (2012) Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A 109:4491-6

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