Cigarette smoking among adolescents and young adults remains one of the most important public health challenges. Almost all smokers begin smoking while in their adolescent years, but smoking becomes entrenched during the young adult years. Understanding more about the factors that promote or protect against smoking progression and nicotine dependence may help us to develop more effective interventions. Also important is understanding how the transition from adolescence to young adulthood, a transition that brings multiple life changes and heightened risk for behavioral problems, influences smoking patterns that have been set in motion during adolescence. This program project will provide an in-depth, multi-method study of the patterns and predictors of smoking patterns from experimentation onward, from adolescence through young adulthood. This continuation builds on and extends our current work by proposing to continue to follow a high risk cohort of individuals, first identified and characterized during mid-adolescence, and who are now in young adulthood. We propose to follow these individuals through their early twenties, the period of highest risk for establishment of smoking and dependence. We will maintain our focus on the social emotional contexts that may influence smoking, and extend this to explore promising genetic markers for the development of dependence. Across projects, we will also characterize, through multiple methods, the development of dependence from the early stages of smoking onward. The projects are linked conceptually through their common consideration of factors that influence the patterns of smoking from adolescence through young adulthood, and methodologically, through their use of a common cohort of participants. Our overriding interest is in identifying, describing, and predicting patterns of progression of smoking and nicotine dependence, considering the dynamic interplay of genetic, social, and emotional contexts. Our proposed program project comprises four research projects and three cores. The four research projects are: 1) Patterns and Predictors of Smoking from Adolescence to Young Adulthood; 2) Proximal Contexts of Young Adult Smoking Patterns; 3) Emotional Indices of Withdrawal in Young Adult Smokers;and 4) Genetic Risk Markers for Smoking Progression. Our three Cores are: 1) Scientific/Administrative Core; 2) Participant Interaction Core;and 3) Data Management, Measurement, and Statistics Core.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098262-07
Application #
8128722
Study Section
Special Emphasis Panel (ZCA1-RPRB-7 (M1))
Program Officer
Morgan, Glen D
Project Start
2002-12-01
Project End
2015-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
7
Fiscal Year
2011
Total Cost
$2,405,997
Indirect Cost
Name
University of Illinois at Chicago
Department
Administration
Type
Schools of Public Health
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Selya, Arielle S; Dierker, Lisa; Rose, Jennifer S et al. (2018) The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. Nicotine Tob Res 20:1272-1277
Selya, Arielle S; Rose, Jennifer S; Dierker, Lisa et al. (2018) Evaluating the mutual pathways among electronic cigarette use, conventional smoking and nicotine dependence. Addiction 113:325-333
Selya, Arielle S; Cannon, Dale S; Weiss, Robert B et al. (2018) The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers. Addict Behav 84:231-237
Xie, Hui; Gao, Weihua; Xing, Baodong et al. (2018) Measuring the Impact of Nonignorable Missingness Using the R Package isni. Comput Methods Programs Biomed 164:207-220
Lin, Xiaolei; Mermelstein, Robin J; Hedeker, Donald (2018) A 3-level Bayesian mixed effects location scale model with an application to ecological momentary assessment data. Stat Med 37:2108-2119
Pugach, Oksana; Cannon, Dale S; Weiss, Robert B et al. (2017) Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res 19:410-416
Dierker, Lisa; Mendoza, William; Goodwin, Renee et al. (2017) Marijuana use disorder symptoms among recent onset marijuana users. Addict Behav 68:6-13
Piasecki, Thomas M; Trela, Constantine J; Mermelstein, Robin J (2017) Hangover Symptoms, Heavy Episodic Drinking, and Depression in Young Adults: A Cross-Lagged Analysis. J Stud Alcohol Drugs 78:580-587
Gorka, Stephanie M; Hedeker, Donald; Piasecki, Thomas M et al. (2017) Impact of alcohol use motives and internalizing symptoms on mood changes in response to drinking: An ecological momentary assessment investigation. Drug Alcohol Depend 173:31-38
Cannon, Dale S; Mermelstein, Robin J; Medina, Tait R et al. (2016) CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res 18:637-41

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