In this renewal, the Data Management, Measurement, and Stafistics (DMMS) Core will confinue to focus on four primary aims: (1) to provide expert data entry, management, and stafistical support across projects;(2) to develop common, psychometricahly sound measures (notably measures of smoking behaviors and outcomes) to use across projects;(3) to implement cross project, integrated analyses;and (4) to propose and develop stafisfical approaches to address key issues related to the analysis of adolescent smoking data. (1) SUPPORT. As in the original project, we will develop and maintain a computerized database for data entry and management, and we will develop detailed documentation ofthe database. We will continue to ufilize rigorous methods for data entry, edifing, and updafing to ensure that the data are clean, consistent, and secure. We will also provide stafistical support and collaboration for all projects. (2) MEASURES. We will assess smoking at mulfiple fimes and with mulfiple measures.
A specific aim of the DMMS Core is to conceptualize and develop measures that will (a) aid in the identificafion of longitudinal smoking patterns and (b) aid in the interpretafion of contexts in which these patterns develop. (3) INTEGRATION. A key feature of the program project is that data will be available from the full cohort through questionnaires administered in Project 1 (four annual assessments) in addifion to data collected from subsets of the cohort in each of the other three projects. A major priority within the DMMS Core is to develop stafisfical models that allow integrated analyses of data from many sources. (4) DEVELOPMENT. Methodological research within the DMMS core will seek to advance the development of statisfical approaches for the analysis of smoking data. These efforts will be focused around three primary issues: the conceptualization/combinafion of mulfiple indices of """"""""dependence,"""""""" individual heterogeneity in smoking development across fime, and characterizing influences of heterogeneity.

Public Health Relevance

Cigarette smoking remains a major public health problem. The DMMS core will provide support for a program of research that examines factors that influence smoking during adolescence and young adult hood. Our overall goal is to increase understanding of the longitudinal pattems of young adult smoking and the emofional and social contexts in which these take place.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA098262-08S1
Application #
8546698
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
8
Fiscal Year
2012
Total Cost
$168,305
Indirect Cost
$60,880
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Cannon, Dale S; Mermelstein, Robin J; Medina, Tait R et al. (2016) CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res 18:637-41
Dierker, Lisa; Selya, Arielle; Rose, Jennifer et al. (2016) Nicotine Dependence and Alcohol Problems from Adolescence to Young Adulthood. Dual Diagn (Foster City) 1:
Crane, Natania A; Gorka, Stephanie M; Giedgowd, Grace E et al. (2016) Adolescent's respiratory sinus arrhythmia is associated with smoking rate five years later. Biol Psychol 118:107-13
Pugach, Oksana; Cannon, Dale S; Weiss, Robert B et al. (2016) Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res :
Hertel, Andrew W; Mermelstein, Robin J (2016) Smoker identity development among adolescents who smoke. Psychol Addict Behav 30:475-83
Piasecki, Thomas M; Hedeker, Donald; Dierker, Lisa C et al. (2016) Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. Psychol Addict Behav 30:484-93
Cannon, Dale S; Medina, Tait R; Mermelstein, Robin J et al. (2016) CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res 18:196-203
Hedeker, Donald; Mermelstein, Robin J; Demirtas, Hakan et al. (2016) A Mixed-effects Location-Scale Model for Ordinal Questionnaire Data. Health Serv Outcomes Res Methodol 16:117-131
Gao, Weihua; Hedeker, Donald; Mermelstein, Robin et al. (2016) A scalable approach to measuring the impact of nonignorable nonresponse with an EMA application. Stat Med 35:5579-5602
Schuster, Randi Melissa; Mermelstein, Robin J; Hedeker, Donald (2016) Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction 111:1466-76

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