This project will test genetic risk markers for smoking trajectory from adolescence through young adulthood in a cohort collected during the initial program project. We will concentrate on genetic risk markers in neuronal nicotinic acetylcholine receptors (nAChRs) but also will consider a limited number of other candidate genes for which there is strong empirical support. We reported previously that CHRNA5-A3-B4 haplotype association with adult nicotine dependence in Whites was more robust in smokers who began daily smoking prior to age 17. This strongly suggests a heightened sensitivity to these risk markers in adolescents. This project uses a unique, prospectively studied adolescent cohort with a rich set of longitudinal phenotypes characterizing smoking progression. We will test possible additive and Interactive effects of genetic risk markers and other variables known to be associated with smoking trajectory (e.g., gender, race, substance use, depression, peer influence and parental smoking). Also, we will examine hypotheses regarding the mediation of genetic associations with smoking trajectoiy by short-term affect regulation and alleviation of nicotine withdrawal by cigarette smoking. Further, we will determine the genetic architecture of nAChR genes within the racial/ethnic groups represented in the study cohort so haplotype-specific genetic risk markers can be tested across races.

Public Health Relevance

Adolescence and young adulthood Is the time of highest risk of becoming nicotine dependent. This project will examine the contribution of genetics to the progression of nicotine dependence and will assess how genetic and non-genetic factors combine to affect risk for nicotine dependence. Results of this research will contribute to more effective smoking prevention and cessation programs in the future.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098262-10
Application #
8734235
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$413,701
Indirect Cost
$73,275
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Cannon, Dale S; Mermelstein, Robin J; Medina, Tait R et al. (2016) CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res 18:637-41
Dierker, Lisa; Selya, Arielle; Rose, Jennifer et al. (2016) Nicotine Dependence and Alcohol Problems from Adolescence to Young Adulthood. Dual Diagn (Foster City) 1:
Crane, Natania A; Gorka, Stephanie M; Giedgowd, Grace E et al. (2016) Adolescent's respiratory sinus arrhythmia is associated with smoking rate five years later. Biol Psychol 118:107-13
Pugach, Oksana; Cannon, Dale S; Weiss, Robert B et al. (2016) Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res :
Hertel, Andrew W; Mermelstein, Robin J (2016) Smoker identity development among adolescents who smoke. Psychol Addict Behav 30:475-83
Piasecki, Thomas M; Hedeker, Donald; Dierker, Lisa C et al. (2016) Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. Psychol Addict Behav 30:484-93
Cannon, Dale S; Medina, Tait R; Mermelstein, Robin J et al. (2016) CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res 18:196-203
Hedeker, Donald; Mermelstein, Robin J; Demirtas, Hakan et al. (2016) A Mixed-effects Location-Scale Model for Ordinal Questionnaire Data. Health Serv Outcomes Res Methodol 16:117-131
Gao, Weihua; Hedeker, Donald; Mermelstein, Robin et al. (2016) A scalable approach to measuring the impact of nonignorable nonresponse with an EMA application. Stat Med 35:5579-5602
Schuster, Randi Melissa; Mermelstein, Robin J; Hedeker, Donald (2016) Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction 111:1466-76

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