Dr. Lee, Principal Investigator of the Core A subcontract at University of Virginia, will communicate with Drs. Chung and Petros, Co-Directors of the Administrative and Services Core A at Emory University, to archive data generated from the program projects, which will be stored at the central database system located in the Urology Department at Emory University and Health System. Analyses of the data will be conducted at both Emory University and the University of Virginia based on an advanced statistical computing environment, including S-PLUS, an object-oriented statistical software (Insightful, Inc.;Seattle, WA) and other programming software. The Emory University School of Public Health and the Department of Health Evaluation Sciences at the University of Virginia have their own NT server with 72 gigabytes of Redundant Array Disk space and 1 gigabyte of RAM. An UltraSpard with 1 gigabyte of RAM and S+ and SAS is available to department members for CPU-intensive computations. The analysis results and reports will be provided to Project Directors and stored at the central database at Emory. Dr. Lee will provide biostatistical and bioinformatics support, including experimental designs and data analysis, as described in the Aims of each research project and microarray and tissue array to seek for genes differentially expressed in the cell culture/animal models and in clinical specimens. Dr. Lee, a long-term collaborator and an experienced biostatistician and the director of microarray/GeneChip facility at the University of Virginia, and Dr. Robert Lyles, an experienced biostatistician from Emory University School of Public Health will consult and collaborate on projects that need their input.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098912-10
Application #
8528351
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2013
Total Cost
$123,576
Indirect Cost
$39,849
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Li, Xiangyan; Chen, Yi-Ting; Hu, Peizhen et al. (2014) Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol Cancer Ther 13:855-66
Miles, Fayth L; Sikes, Robert A (2014) Insidious changes in stromal matrix fuel cancer progression. Mol Cancer Res 12:297-312
Warren, Curtis R; Grindel, Brian J; Francis, Lewis et al. (2014) Transcriptional activation by NF?B increases perlecan/HSPG2 expression in the desmoplastic prostate tumor microenvironment. J Cell Biochem 115:1322-33
Shao, Chen; Liao, Chun-Peng; Hu, Peizhen et al. (2014) Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer. PLoS One 9:e88967
Pradhan-Bhatt, Swati; Harrington, Daniel A; Duncan, Randall L et al. (2014) A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland. Laryngoscope 124:456-61
Shi, Changhong; Wu, Jason Boyang; Chu, Gina C-Y et al. (2014) Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1?/OATPs signaling axis. Oncotarget 5:10114-26
Tighiouart, Mourad; Piantadosi, Steven; Rogatko, André (2014) Dose finding with drug combinations in cancer phase I clinical trials using conditional escalation with overdose control. Stat Med 33:3815-29
Fong, Eliza L S; Martinez, Mariane; Yang, Jun et al. (2014) Hydrogel-based 3D model of patient-derived prostate xenograft tumors suitable for drug screening. Mol Pharm 11:2040-50
Tighiouart, Mourad; Liu, Yuan; Rogatko, André (2014) Escalation with overdose control using time to toxicity for cancer phase I clinical trials. PLoS One 9:e93070
Josson, Sajni; Gururajan, Murali; Hu, Peizhen et al. (2014) miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res 20:4636-46

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