The Administration and Biostatistics Core will provide centralized grant administration, communications, data sharing, and statistical analyses for the projects. This Core also serves to amalgamate the investigators, their experimental findings and their ideas, promote translational efforts and direct efforts toward the Program goals and outcomes. In addition, the Biostatistics and Data Integration part of this core will create and operate a secure web site for the interchange of data, communications, and the evaluation of Program progress.
Specific Aims i nclude:
Aim 1. Provide basic administrative services to the investigators. ? Service includes the management of supplies, filing, development of memos, meeting minutes and communications covering all operations. The Core will provide investigators with clear lines of scientific and administrative communication to promote collaboration, aid in the prioritization of resources, and facilitate resolution of any problems that affect team members. ? Provide publication services to the investigators for project-related communications.
Aim 2. Provide data management and statistical analyses for all projects. ? To collaborate with project investigators in the formulation of hypotheses and study design. ? To conduct and direct the statistical analysis of data including both descriptive summary statistics and sophisticated inferential procedures. ? Provide timely review, quality assurance, and dissemination of the results gleaned from investigations. ? To install data prioritization evaluation and an inter-institutional secure website for sharing and storing databases. Provide access in real-time to data sets and standardization of data sets to permit data managers from all institutions to have input on statistics and direct modeling and experimental design.
Aim 3. Organize Scientific and Advisory Board Meetings ? Monthly Steering Committee Meetings (Project Leaders, Core Directors, and key staff members). ? Weekly PPG Retrovirology Laboratory Scientific Data Meetings (all project members and their labs) ? Annual Internal and External Scientific Advisory Board (ISAB &ESAB) meetings. Panel of experts shall assess the Program effectiveness and experimental progress, research directions, statistical evaluation, and admin effectiveness. Each board will review experimental findings and translational outcomes, help prioritize investigations, review collaborations, and evaluate concepts that emerge.
Aim 4. Provide overall fiscal review, accounting, and real time budgets analyses.

Public Health Relevance

The Administration and Biostatistics Core is essential for the functions of the Program as an engine for discovery and will provide critical support for planning of studies and design of experiments, statistical analyses and display of data, and data management and integrity. This support is designed to ensure that studies yield reliable conclusions, resources are efficiently used, and exploratory analyses uncover important leads.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA100730-11A1
Application #
8742036
Study Section
Special Emphasis Panel (ZCA1-RPRB-J (M1))
Project Start
2014-09-23
Project End
2019-08-31
Budget Start
2014-09-23
Budget End
2015-08-31
Support Year
11
Fiscal Year
2014
Total Cost
$187,558
Indirect Cost
$49,389
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
M Parrula, M Cecilia; Fernandez, Soledad A; Landes, Kristina et al. (2014) Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness. Virus Res 189:206-13
Dissinger, Nathan; Shkriabai, Nikoloz; Hess, Sonja et al. (2014) Identification and characterization of HTLV-1 HBZ post-translational modifications. PLoS One 9:e112762
Soodgupta, Deepti; Hurchla, Michelle A; Jiang, Majiong et al. (2013) Very late antigen-4 (*(4)*(1) Integrin) targeted PET imaging of multiple myeloma. PLoS One 8:e55841
Yang, Chang; Davis, Jennifer L; Zeng, Rong et al. (2013) Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation. Cancer Discov 3:212-23
Kannian, Priya; Fernandez, Soledad; Jones, Kathryn S et al. (2013) Human T lymphotropic virus type 1 SU residue 195 plays a role in determining the preferential CD4+ T cell immortalization/transformation tropism. J Virol 87:9344-52
Hurchla, M A; Garcia-Gomez, A; Hornick, M C et al. (2013) The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects. Leukemia 27:430-40
Jacob, Aishwarya G; O'Brien, Dennis; Singh, Ravi K et al. (2013) Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. Neoplasia 15:1049-63
Sharma, Amit; Larue, Ross C; Plumb, Matthew R et al. (2013) BET proteins promote efficient murine leukemia virus integration at transcription start sites. Proc Natl Acad Sci U S A 110:12036-41
Kessl, Jacques J; Jena, Nivedita; Koh, Yasuhiro et al. (2012) Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem 287:16801-11
Heller, Emanuela; Hurchla, Michelle A; Xiang, Jingyu et al. (2012) Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res 72:897-907

Showing the most recent 10 out of 106 publications