The Administrative Core A will facilitate interactions between Program members and provide biostatistical support for Projects and Cores. Communication between POI members is critical for success of the Program. Effective communication will promote collaboration and synergy between projects, and accelerate the pace of discovery. Regular internal and external review of scientific progress and evaluation of cores will promote research excellence and ensure that projects are provided with the highest quality services. Application of appropriate statistical tools is essential for rigorous evaluation of hypotheses and for improving experiment design. Functions ofthe Administrative Core include promoting communication and collaboration within the Program by supporting web-based communication between the University of Virginia and the University of Colorado, organizing regular scientific meetings, and providing administrative support to Project Leaders and Core Directors. The Core will also oversee the review of scientific quality and fiscal management of the Projects and Cores. Another key activity of the Core is to provide statistical support and instruction for the Program. This involves assisting in the design and analysis of in vitro and in vivo studies, development and application of novel statistical methodologies in support of emerging Program objectives, and provision of training in statistical methods.

Public Health Relevance

Prostate cancer is the second leading cause of deaths due to cancer in North American men. Our research is designed to explain how prostate cancer progresses to a state that is resistant to current therapies. This knowledge base will enable the design of new therapeutic strategies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA104106-08
Application #
8744374
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (J1))
Project Start
2013-09-01
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
8
Fiscal Year
2013
Total Cost
$187,896
Indirect Cost
$74,706
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Kumar, Pankaj; Kuscu, Canan; Dutta, Anindya (2016) Biogenesis and Function of Transfer RNA-Related Fragments (tRFs). Trends Biochem Sci 41:679-89
Agarwal, Neeraj; Dancik, Garrett M; Goodspeed, Andrew et al. (2016) GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis. Cancer Res 76:5175-85
Reon, Brian J; Dutta, Anindya (2016) Biological Processes Discovered by High-Throughput Sequencing. Am J Pathol 186:722-32
Sakurai, Kouhei; Reon, Brian J; Anaya, Jordan et al. (2015) The lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus. Mol Cancer Res 13:828-38
Mueller, Adam C; Cichewicz, Magdalena A; Dey, Bijan K et al. (2015) MUNC, a long noncoding RNA that facilitates the function of MyoD in skeletal myogenesis. Mol Cell Biol 35:498-513
Borah, Sumit; Xi, Linghe; Zaug, Arthur J et al. (2015) Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science 347:1006-10
Kumar, Pankaj; Mudunuri, Suresh B; Anaya, Jordan et al. (2015) tRFdb: a database for transfer RNA fragments. Nucleic Acids Res 43:D141-5
Earl, Julie; Rico, Daniel; Carrillo-de-Santa-Pau, Enrique et al. (2015) The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies. BMC Genomics 16:403
Dillon, Laura W; Kumar, Pankaj; Shibata, Yoshiyuki et al. (2015) Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity. Cell Rep 11:1749-59
Zboray, Lori; Pluciennik, Anna; Curtis, Dana et al. (2015) Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA. Cell Rep 13:2312-23

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