Abstract

Mammographic breast density is a strong predictor of breast cancer risk. At this present time, little is known? about which attribute(s) of mammographic density also contributes to breast cancer risk. To gain insight? into this question this Program Project Grant seeks to use human tissue to explore the biologic connection? between mammographic density and molecular markers for breast cancer risk. To accomplish these goals,? the Core will provide services that are fundamental to all projects within the Program Project Grant? application.? The primary goals of the Tissue and Biostatistics Core are to process breast tissue for study by the? Program Project Investigators and provide high quality characterization and biostatistical analysis of? samples. Core personnel will process fresh tissue from donors in a systematic manner, which will allow? correlation of tissue blocks with density images for Projects 1 and 2. The Core will coordinate routine tissue? processing, embedding, sectioning and staining through the UCSF Comprehensive Cancer Center Tissue? Core. Routine immunohistochemistry stains for Projects 2 and 3 will be coordinated though the UCSF? Comprehensive Cancer Center Immunohistochemistry and Molecular Pathology Core. Core pathologists? will be responsible for the interpretation of H&E sections and immunohistochemistry stains. The Core? biostatistician will be involved in study design and statistical analyses of data obtained by Projects 1, 2, 3,? and 4.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA107584-03
Application #
7615727
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
3
Fiscal Year
2008
Total Cost
$130,221
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Gascard, Philippe; Tlsty, Thea D (2016) Carcinoma-associated fibroblasts: orchestrating the composition of malignancy. Genes Dev 30:1002-19
Rees, Elliott; Kendall, Kimberley; Pardiñas, Antonio F et al. (2016) Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia. JAMA Psychiatry 73:963-969
Drake, Christopher R; Estévez-Salmerón, Luis; Gascard, Philippe et al. (2015) Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Org Biomol Chem 13:11078-86
DeFilippis, Rosa Anna; Fordyce, Colleen; Patten, Kelley et al. (2014) Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Res 74:5032-5044
Dumont, Nancy; Liu, Bob; Defilippis, Rosa Anna et al. (2013) Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia 15:249-62
Roy, Somdutta; Gascard, Philippe; Dumont, Nancy et al. (2013) Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A 110:4598-603
Kerlikowske, Karla; Zhu, Weiwei; Hubbard, Rebecca A et al. (2013) Outcomes of screening mammography by frequency, breast density, and postmenopausal hormone therapy. JAMA Intern Med 173:807-16
Braithwaite, Dejana; Mandelblatt, Jeanne S; Kerlikowske, Karla (2013) To screen or not to screen older women for breast cancer: a conundrum. Future Oncol 9:763-6
DeFilippis, Rosa Anna; Chang, Hang; Dumont, Nancy et al. (2012) CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov 2:826-39
Fordyce, Colleen A; Patten, Kelley T; Fessenden, Tim B et al. (2012) Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Res 14:R155

Showing the most recent 10 out of 19 publications