The overall purpose of Core A is to provide administrative support to the projects and cores of the Program, which enable the Program as a whole to meet its scientific mission more efficiently and expeditiously. The Core achieves this by carrying out a number of specific functions that relieve PIs of administrative concerns and enhance the coordination of work within the Program and the productive interaction ofthe Program with the larger research community. These functions will include:
Aim 1 : To ensure that the work carried out under the auspices of this Program meet the requirements of the NCI and NIH Aim 2: To coordinate meetings among the Program investigators and their laboratories Aim 3: To provide financial accounting to the PI and Project Leaders of each project and core.
Aim 4 : To coordinate communication between the investigators of the Program and Scientific Advisory Board.
Aim 5 : To coordinate travel related to the Program for the investigators and facilitate submission of manuscripts emanating from Program activities.
Aim 6 : To communicate the work emanating from our Program to the wider scientific community.

Public Health Relevance

The Administration Core plays an essential support role for all of the scientific projects of the Program, which are focused on understanding how Notch receptors are activated and turn on the expression of genes that drive the growth and survival of cancer cells. Thus, this shared resource is critical for the success of studies designed to elucidate fundannental aspects of how Notch signaling causes cancer, which in turn is likely to lead to new diagnostic approaches and therapies.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01CA119070-08
Application #
8701034
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Yashiro-Ohtani, Yumi; Wang, Hongfang; Zang, Chongzhi et al. (2014) Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A 111:E4946-53
Arnett, Kelly L; Blacklow, Stephen C (2014) Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods Mol Biol 1187:231-45
Wang, Hongfang; Zang, Chongzhi; Taing, Len et al. (2014) NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A 111:705-10
Dail, Monique; Wong, Jason; Lawrence, Jessica et al. (2014) Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia. Nature 513:512-6
Gerhardt, Dawson M; Pajcini, Kostandin V; D'altri, Teresa et al. (2014) The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev 28:576-93
Stoeck, Alexander; Lejnine, Serguei; Truong, Andrew et al. (2014) Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov 4:1154-67
Tiyanont, Kittichoat; Wales, Thomas E; Siebel, Christian W et al. (2013) Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. J Mol Biol 425:3192-204
Andrawes, Marie Blanke; Xu, Xiang; Liu, Hong et al. (2013) Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem 288:25477-89
Chiang, Mark Y; Shestova, Olga; Xu, Lanwei et al. (2013) Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood 121:905-17
Blacklow, Stephen C (2013) Refining a Jagged edge. Structure 21:2100-1

Showing the most recent 10 out of 38 publications