Optimal scientific interpretation of translational research requires careful data and sample collection that is analyzed with basic science techniques, correlated to human outcomes, and the knowledge gained translated back to clinical care (e.g. bench-to-bedside research). Critical to this process are 1.) accurate validation that the clinical information collected is correct and that the data are handled, categorized, maintained, and analyzed accurately;and 2.) a need for high quality specimens of various types, including blood and tissue samples. Therefore, the goal of this Core is to provide a central repository for clinical data and subject samples for use in the scientific projects of this program project using careful selection and data categorization with fundamental integration with the Project and Core Pis at all experimental phases ncluding study and database design, sample size determination, data collection, and final analysis. This is a novel resource in its scope and detail for thyroid cancer and collection of unique samples and datapoints specifically organized for support of this P-01 proposal. In support of this objective, the Specific Aims of the Integrated Clinical Information &Pathology Sample Repository Core (Core A) include: 1. Creation of a human data repository of clinical information including subject diagnosis, treatment, pathology (including AJCC cancer staging parameters), tumor markers, and detailed family history. 2. Creation of human subjects'germline sample repository collected from biological samples (blood, buccal swabs, and/or saliva). 3. Creation of a thyroid tissue bank to include fine needle aspiration (FNA), fresh frozen and paraffin embedded thyroid tissue (tumor and matching normal) and non-medullary thyroid cancer tissue microarrays (TMA).

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-GRB-S)
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Ohio State University
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Yu, Wanfeng; Ni, Ying; Saji, Motoyasu et al. (2017) Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells. Hum Mol Genet 26:1365-1375
Gudmundsson, Julius; Thorleifsson, Gudmar; Sigurdsson, Jon K et al. (2017) A genome-wide association study yields five novel thyroid cancer risk loci. Nat Commun 8:14517
Azmat, Umal; Porter, Kyle; Senter, Leigha et al. (2017) Thyroglobulin Liquid Chromatography-Tandem Mass Spectrometry Has a Low Sensitivity for Detecting Structural Disease in Patients with Antithyroglobulin Antibodies. Thyroid 27:74-80
Chen, Hannah H; Händel, Norman; Ngeow, Joanne et al. (2017) Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol 139:607-620.e15
Rossfeld, Kara K; Justiniano, Steven E; Ding, Haiming et al. (2017) Biological Evaluation of a Fluorescent-Imaging Agent for Medullary Thyroid Cancer in an Orthotopic Model. J Clin Endocrinol Metab 102:3268-3277
Saporito, Donika; Brock, Pamela; Hampel, Heather et al. (2017) Penetrance of a rare familial mutation predisposing to papillary thyroid cancer. Fam Cancer :
Byrd, Victoria; Getz, Ted M; Padmanabhan, Roshan et al. (2017) Microbiome in PTEN hamartoma tumor syndrome. Endocr Relat Cancer :
Tomsic, Jerneja; Fultz, Rebecca; Liyanarachchi, Sandya et al. (2017) Variants in microRNA genes in familial papillary thyroid carcinoma. Oncotarget 8:6475-6482
Ni, Ying; Seballos, Spencer; Fletcher, Benjamin et al. (2017) Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma. Hum Mol Genet 26:243-257
Ashtekar, Amruta; Huk, Danielle; Magner, Alexa et al. (2017) Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype. Endocr Relat Cancer 24:579-591

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