Specific Aims : The Administration Core will provide oversight and Administrative, Biostatistics and Clinical Research support for the projects and cores that comprise the Host Defense Regulation and Viral Oncogenesis Program. The goal of the Administration Core is to monitor the activities of the program components and facilitate communication and collaborations among the participants of this program project application.
The specific aims of the Administrative Core areas follow: 1) To provide administrative oversight and support for the projects and cores 2) To facilitate communication and collaboration among investigators by coordinating all program project meetings including Internal and External Advisory Boards meetings 3) To provide budgetary and fiscal management 4) To provide biostatistics support for design, implementation and interpretation studies proposed 5) To provide clinical research support for the clinical components of the program project
(See Instructions): The Administration core will assist the POl projects with the experimental design and data analysis, data storage and clinical management needed to support the specific aims of the various projects. The benefit to overall public health is elucidation of mechanism of ATLL development and possible improved treatments.
|Zhou, Qinjie; Lavorgna, Alfonso; Bowman, Melissa et al. (2015) Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. J Biol Chem 290:14729-39|
|Betancourt, Dillon; Ramos, Juan Carlos; Barber, Glen N (2015) Retargeting Oncolytic Vesicular Stomatitis Virus to Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia. J Virol 89:11786-800|
|Bayraktar, Ulas Darda; Diaz, Luis A; Ashlock, Brittany et al. (2014) Zidovudine-based lytic-inducing chemotherapy for Epstein-Barr virus-related lymphomas. Leuk Lymphoma 55:786-94|
|Gao, Linlin; Harhaj, Edward William (2013) HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-?B activation and HTLV-1 replication. J Virol 87:13640-54|
|Charoenthongtrakul, Soratree; Gao, Linlin; Parvatiyar, Kislay et al. (2013) RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One 8:e53717|
|Bhatt, Shruti; Ashlock, Brittany M; Toomey, Ngoc L et al. (2013) Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. J Clin Invest 123:2616-28|
|Lavorgna, Alfonso; Harhaj, Edward W (2013) Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-*B activation? Future Virol 8:223-227|
|Shembade, Noula; Harhaj, Edward W (2012) Regulation of NF-?B signaling by the A20 deubiquitinase. Cell Mol Immunol 9:123-30|
|Lavorgna, Alfonso; Harhaj, Edward W (2012) EBV LMP1: New and shared pathways to NF-ýýB activation. Proc Natl Acad Sci U S A 109:2188-9|
|Harhaj, Edward W; Dixit, Vishva M (2012) Regulation of NF-?B by deubiquitinases. Immunol Rev 246:107-24|
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