Core A functions to provide the leadership, interaction and coordination between the different projects of this PPG in order to facilitate them in meeting their scientific goals. The Core will oversee the organization of regular meeting of the scientists participating in this program project and core leaders, to hold executive meetings of the project leaders (steering committee) and to review progress on the overall goals of the PPG as a whole, in part through the annual meeting with the internal and external scientific advisory boards. The personnel of administrative assistant and program manager together with the PI of this PPG will assure seaming less operation of scientific agenda and administrative matters. Core A will also provide the administrative support which includes the monitoring of funds and research allocations. The steering committee of this program project will review expenditures and resource allocations for the projects and cores, at least twice a year. The administrative core will also be responsible for collating the reports from the scientific advisory boards, following up on SAB recommendations, as well as writing and transmitting the annual progress report to NIH. The administrative core will oversee a seminar program that will be tailored for program needs and be integrated with the cancer center seminar series at BIMR. Overseeing the launch and maintenance of a Web page for this PPG will allow distribution of findings among the global community, while enabling sharing protocols, reagents as well as information among the projects in real time.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA128814-05
Application #
8528361
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$81,856
Indirect Cost
$39,879
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Maruyama, Takeshi; Araki, Toshihiro; Kawarazaki, Yosuke et al. (2014) Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Sci Signal 7:ra8
Kim, H; Claps, G; Moller, A et al. (2014) Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. Oncogene 33:2004-10
Scortegagna, Marzia; Kim, Hyungsoo; Li, Jian-Liang et al. (2014) Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet 10:e1004348
Qi, Jianfei; Kim, Hyungsoo; Scortegagna, Marzia et al. (2013) Regulators and effectors of Siah ubiquitin ligases. Cell Biochem Biophys 67:15-24
Feng, Yongmei; Lau, Eric; Scortegagna, Marzia et al. (2013) Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11. Pigment Cell Melanoma Res 26:136-42
Barile, Elisa; De, Surya K; Feng, Yongmei et al. (2013) Synthesis and SAR studies of dual AKT/NF-*B inhibitors against melanoma. Chem Biol Drug Des 82:520-33
Stebbins, John L; Santelli, Eugenio; Feng, Yongmei et al. (2013) Structure-based design of covalent Siah inhibitors. Chem Biol 20:973-82
Filipp, Fabian V; Scott, David A; Ronai, Ze'ev A et al. (2012) Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res 25:375-83
Feng, Yongmei; Barile, Elisa; De, Surya K et al. (2011) Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-*B pathways. Pigment Cell Melanoma Res 24:703-13
Scott, David A; Richardson, Adam D; Filipp, Fabian V et al. (2011) Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J Biol Chem 286:42626-34

Showing the most recent 10 out of 18 publications