Project 3 extends the ITC survey methodology outlined in Project 1, by undertaking supplementary data collection in six ITC countries, two developed (i.e., US &UK) and four LMICs (i.e., China, Malaysia, Mexico, Thailand) with the goal of examining variation in cigarette characteristics among leading brand varieties, and exploring how these differences relate to tobacco control policies, tobacco uses behaviors, and exposure to selected tobacco smoke constituents in different countries. Project 3 has three specific aims.
Aim 1 involves tracking the tobacco market and establishing a repository of leading cigarette brands, linkable to retailer-level evaluations of product marketing and pricing activities.
Aim 2 has two components related to the construction and composition of cigarettes: (a) characterizing cigarettes obtained for the repository as well as from individuals for key design and physical features that can influence smoke chemistries and consumer acceptability;and (b) developing a panel of physical features of cigarettes brands that can be used to reliably distinguish legitimate from counterfeit brands.
Aim 3, which seeks to examine person-level variation in smoking behaviors and exposures, also involves two components: (a) examining in a subsample of the ITC cohort participants in Project 1 the extent to which variation in tobacco use behaviors can be explained by measures of nicotine intake and nicotine metabolism;and (b) comparing how tobacco use behaviors, nicotine intake and nicotine metabolism are related to indicators of social deprivation/socioeconomic status, both within and between high resource and LMICs.

Public Health Relevance

The proposed project seeks to understand how and why differences in smokers and products may or may not influence reactions to tobacco control policies in different countries. Understanding these issues can provide important information to increase the effectivenessof these policies to help smokers quit and avoid tobacco use.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
United States
Zip Code
Heckman, Bryan W; Cummings, K Michael; Kasza, Karin A et al. (2017) Effectiveness of Switching Smoking-Cessation Medications Following Relapse. Am J Prev Med 53:e63-e70
El-Toukhy, Sherine; Choi, Kelvin; Hitchman, Sara C et al. (2017) Banning tobacco price promotions, smoking-related beliefs and behaviour: findings from the International Tobacco Control Four Country (ITC 4C) Survey. Tob Control :
Snider, Sarah E; Cummings, K Michael; Bickel, Warren K (2017) Behavioral economic substitution between conventional cigarettes and e-cigarettes differs as a function of the frequency of e-cigarette use. Drug Alcohol Depend 177:14-22
Streck, Joanna M; Regan, Susan; Chang, Yuchiao et al. (2017) Examining the effects of illicit drug use on tobacco cessation outcomes in the Helping HAND 2 randomized controlled trial. Drug Alcohol Depend 178:586-592
Gravely, Shannon; Fong, Geoffrey T; Driezen, Pete et al. (2016) The impact of the 2009/2010 enhancement of cigarette health warning labels in Uruguay: longitudinal findings from the International Tobacco Control (ITC) Uruguay Survey. Tob Control 25:89-95
Cooper, Jae; Borland, Ron; McKee, Sherry A et al. (2016) Depression motivates quit attempts but predicts relapse: differential findings for gender from the International Tobacco Control Study. Addiction 111:1438-47
Yong, Hua-Hie; Borland, Ron; Hammond, David et al. (2016) Smokers' reactions to the new larger health warning labels on plain cigarette packs in Australia: findings from the ITC Australia project. Tob Control 25:181-7
Huang, Li-Ling; Thrasher, James F; Reid, Jessica L et al. (2016) Predictive and External Validity of a Pre-Market Study to Determine the Most Effective Pictorial Health Warning Label Content for Cigarette Packages. Nicotine Tob Res 18:1376-81
Riddle Jr, Philip J; Newman-Norlund, Roger D; Baer, Jessica et al. (2016) Neural response to pictorial health warning labels can predict smoking behavioral change. Soc Cogn Affect Neurosci 11:1802-1811
Osman, Amira; Thrasher, James F; Cayir, Ebru et al. (2016) Depressive symptoms and responses to cigarette pack warning labels among Mexican smokers. Health Psychol 35:442-53

Showing the most recent 10 out of 152 publications