National Institute of Health (NIH)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1)
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Sanford-Burnham Medical Research Institute
La Jolla
United States
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Hassan-Mohamed, I; Giorgio, C; Incerti, M et al. (2014) UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. Br J Pharmacol 171:5195-208
Vargas, Lina M; Leal, Nancy; Estrada, Lisbell D et al. (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-? oligomers. PLoS One 9:e92309
Lamberto, Ilaria; Lechtenberg, Bernhard C; Olson, Erika J et al. (2014) Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor. ACS Chem Biol 9:2787-95
Barile, Elisa; Wang, Si; Das, Swadesh K et al. (2014) Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system. ChemMedChem 9:1403-12
Incerti, Matteo; Tognolini, Massimiliano; Russo, Simonetta et al. (2013) Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem 56:2936-47
Wang, Si; Noberini, Roberta; Stebbins, John L et al. (2013) Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clin Cancer Res 19:128-37
Mercurio, Flavia A; Marasco, Daniela; Pirone, Luciano et al. (2013) Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights. Chembiochem 14:100-6
Duggineni, Srinivas; Mitra, Sayantan; Noberini, Roberta et al. (2013) Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4. Biochem Pharmacol 85:507-13
Wu, Bainan; Zhang, Ziming; Noberini, Roberta et al. (2013) HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol 20:19-33
Duggineni, Srinivas; Mitra, Sayantan; Lamberto, Ilaria et al. (2013) Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor. ACS Med Chem Lett 4:

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