The Administrative Core will provide coordination and oversight of the activities of the Projects and Cores in this Program Project, and will maximize interactions and potential synergies among Project Leaders, Core Directors, and laboratory personnel. The Core will coordinate data access and management of data resources, and will provide expert bioinformatic and biostatistical support for the Projects and Core A. This support will be provided by dedicated personnel with appropriate expertise to serve the specialized needs of this Program, while leveraging but not duplicating the outstanding services provided by the respective Biomedical Informatics and Biostatistical Shared Resources in the Herbert Irving Comprehensive Cancer Center (HICCC). To facilitate integration of the program and effective communication among its various members, the Core will organize monthly meetings comprised of two parts;namely, (i) Research presentations, which will include all program participants, as well as Internal Advisory Board members;and (ii) Executive meetings, which will be limited to the Executive Committee (Drs. Shen, Abate-Shen, Gelmann, and Cordon-Cardo) and members of the Internal Advisory Board. The latter will provide a forum for candid assessment of research progress, oversight of Core utilization, and prioritization of resources and objectives. An important function of the Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and compliance with regulatory requirements. Finally, the Core will organize an annual full-day review of the Program Project by members of the Internal and External Advisory Boards, who will provide detailed feedback on research progress and future directions, as well as advice on program management. This Core will have the following specific aims: (1) Coordination of the overall program by maintaining the overall organization of the program and establishing mechanisms for effective interaction among its personnel;(2) Data and resource management by promoting effective utilization of Core A, supporting access to a SharePoint server that will store research presentations and databases, and by facilitating data and resource sharing with external laboratories;(3) Bioinformatic and Biostatistical support for the Projects and Core A, which will be provided by expert dedicated staff who will interface with these respective Shared Resources of the HICCC. (4) Review of the Program Project by Internal and External Advisory Boards to evaluate ongoing progress of each Project, review the functionality of the Cores, and provide advice on future research directions.

Public Health Relevance

The Administrative Core will promote outstanding research on the molecular mechanisms of prostate cancer initiation by ensuring the smooth and efficient functioning of the overall program, providing oversight for its operations, coordinating data analyses for bioinformatic and biostatistical support, and promoting the sharing of data and resources within the Program Project as well as with the broad external community of cancer researchers.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01CA154293-04
Application #
8724938
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Le Magnen, Clémentine; Dutta, Aditya; Abate-Shen, Cory (2016) Optimizing mouse models for precision cancer prevention. Nat Rev Cancer 16:187-96
Dutta, Aditya; Le Magnen, Clémentine; Mitrofanova, Antonina et al. (2016) Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science 352:1576-80
Zhang, Hailan; Zheng, Tian; Chua, Chee Wai et al. (2016) Nkx3.1 controls the DNA repair response in the mouse prostate. Prostate 76:402-8
Mitrofanova, Antonina; Aytes, Alvaro; Zou, Min et al. (2015) Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models. Cell Rep 12:2060-71
Bowen, Cai; Zheng, Tian; Gelmann, Edward P (2015) NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage. Cancer Res 75:2686-98
Shibata, Maho; Shen, Michael M (2015) Stem cells in genetically-engineered mouse models of prostate cancer. Endocr Relat Cancer 22:T199-208
Shen, Michael M (2015) Cancer: The complex seeds of metastasis. Nature 520:298-9
Shen, Michael M (2015) Illuminating the Properties of Prostate Luminal Progenitors. Cell Stem Cell 17:644-6
Song, Liang-Nian; Silva, Jose; Koller, Antonius et al. (2015) The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase. Mol Cancer Res 13:913-22
Lee, Suk Hyung; Shen, Michael M (2015) Cell types of origin for prostate cancer. Curr Opin Cell Biol 37:35-41

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