The Analytical Core led by Dr. Hongyu Zhao will support the statistics, bioinformatics, implementation, and data analysis needs of all the Projects of this Program Project. In coordination with the Administrative Core led by Dr. Yung-Chi Cheng, this Core will function to conduct statistical analysis of the clinical trial data from Project 1, assist in the analysis of potential biomarkers and their associations with patient responses from Project 2, and implement and apply the novel statistical methods to be developed in Project 3. This Core will also provide a training environment for program project personnel on software tools on data analysis and interpretation.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-GRB-S)
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Yale University
New Haven
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Tan, Hor-Yue; Wang, Ning; Lam, Wing et al. (2018) Targeting tumour microenvironment by tyrosine kinase inhibitor. Mol Cancer 17:43
Sun, Jiehuan; Herazo-Maya, Jose D; Huang, Xiu et al. (2018) Distance-correlation based gene set analysis in longitudinal studies. Stat Appl Genet Mol Biol 17:
Lam, Wing; Ren, Yongshen; Guan, Fulan et al. (2018) Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906). Front Pharmacol 9:1324
Guan, Fulan; Lam, Wing; Hu, Rong et al. (2018) Majority of Chinese Medicine Herb Category ""Qing Re Yao"" Have Multiple Mechanisms of Anti-inflammatory Activity. Sci Rep 8:7416
Chao, Jung; Dai, Yuntao; Cheng, Hao-Yuan et al. (2017) Improving the Concentrations of the Active Components in the Herbal Tea Ingredient, Uraria crinita: The Effect of Post-harvest Oven-drying Processing. Sci Rep 7:38763
Liu, Yiyi; Zhao, Hongyu (2017) Variable importance-weighted Random Forests. Quant Biol 5:338-351
Sun, Jiehuan; Herazo-Maya, Jose D; Kaminski, Naftali et al. (2017) A Dirichlet process mixture model for clustering longitudinal gene expression data. Stat Med 36:3495-3506
Lin, Zhixiang; Wang, Tao; Yang, Can et al. (2017) On joint estimation of Gaussian graphical models for spatial and temporal data. Biometrics 73:769-779
Sun, Jiehuan; Warren, Joshua L; Zhao, Hongyu (2017) A Bayesian semiparametric factor analysis model for subtype identification. Stat Appl Genet Mol Biol 16:145-158
Zhu, Ruoqing; Zhao, Ying-Qi; Chen, Guanhua et al. (2017) Greedy outcome weighted tree learning of optimal personalized treatment rules. Biometrics 73:391-400

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