The mission of the engineering services core is to provide a common base of software and hardware systems and interfaces to support the five MRI guided cancer ablation program projects: 1) MR-guided HIFU of Soft Tissue Tumors, 2) Minimally Invasive MRI-Guided Management of Prostate Disease, 3) MR-Guided Precision Thermal Therapy of Retroperitoneal Tumors, 4) MRI Methods for Guiding Focused Ultrasound in the Brain, and 5) MR-Guided RF ablation. The software services will adapt the HeartVista real-time MRI package for interventional MRI applications and create tailored application specific interfaces, sequences, and control processes for each therapy. These services will provide in room projection display, needle placement and tracking software, real-time MRI temperature mapping and 3D visualization tools for iceball formation, high-intensity focused ultrasound (HIFU) targeting and RF ablation volumes. For each ablation modality (cryo-ablation, HIFU, RF), treatment planning utilities can be developed. The hardware services will provide customized active device visualization methods for MRI, to support MR-Guided RF ablation, needle tracking for cryo-ablation and

Public Health Relevance

All forms of ablation will benefit from a well-integrated hardware and software interface with an MRI scanner. The engineering core will develop methods and interfaces to allow a very user-friendly control of ablation by MRI. This should reduce the treatment time and improve the targeting to cancer tumors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA159992-02
Application #
8555399
Study Section
Special Emphasis Panel (ZCA1-GRB-P (M1))
Project Start
2011-09-22
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$226,981
Indirect Cost
$74,554
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Adams, Matthew S; Salgaonkar, Vasant A; Scott, Serena J et al. (2017) Integration of deployable fluid lenses and reflectors with endoluminal therapeutic ultrasound applicators: Preliminary investigations of enhanced penetration depth and focal gain. Med Phys 44:5339-5356
Gibbons, Eric K; Le Roux, Patrick; Vasanawala, Shreyas S et al. (2017) Body Diffusion Weighted Imaging Using Non-CPMG Fast Spin Echo. IEEE Trans Med Imaging 36:549-559
Ghanouni, Pejman; Kishore, Sirish; Lungren, Matthew P et al. (2017) Treatment of Low-Flow Vascular Malformations of the Extremities Using MR-Guided High Intensity Focused Ultrasound: Preliminary Experience. J Vasc Interv Radiol 28:1739-1744
Johnson, Ethan M; Vyas, Urvi; Ghanouni, Pejman et al. (2017) Improved cortical bone specificity in UTE MR Imaging. Magn Reson Med 77:684-695
Weber, Hans; Taviani, Valentina; Yoon, Daehyun et al. (2017) MR thermometry near metallic devices using multispectral imaging. Magn Reson Med 77:1162-1169
Dababou, Susan; Marrocchio, Cristina; Rosenberg, Jarrett et al. (2017) A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound. J Ther Ultrasound 5:9
Aggarwal, Kamal; Joshi, Kiran R; Rajavi, Yashar et al. (2017) A Millimeter-Wave Digital Link for Wireless MRI. IEEE Trans Med Imaging 36:574-583
Weber, Hans; Ghanouni, Pejman; Pascal-Tenorio, Aurea et al. (2017) MRI monitoring of focused ultrasound sonications near metallic hardware. Magn Reson Med :
Ghanouni, Pejman; Dobrotwir, Andrew; Bazzocchi, Alberto et al. (2017) Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol 27:732-740
Bitton, Rachel R; Webb, Taylor D; Pauly, Kim Butts et al. (2016) Improving thermal dose accuracy in magnetic resonance-guided focused ultrasound surgery: Long-term thermometry using a prior baseline as a reference. J Magn Reson Imaging 43:181-9

Showing the most recent 10 out of 56 publications