This Program Project aims to develop a comprehensive treatment approach that engages all smokers visiting healthcare settings in treatment that efficiently and effectively helps them stop smoking. This will be achieved by: 1) developing a smoker recruitment strategy to be used in real-world primary care clinics that is based on enhancements to the electronic health record (EHR), and 2) by developing a chronic care treatment for smoking that is effective across all phases of smoking treatment: enhancing quitting motivation, aiding cessation, preventing relapse, and aiding relapse recovery. The proposed research will use powerful research methods that call for testing multiple intervention components in multiple linked experiments. Thus, the proposed research requires implementation strategies that support effective modification of the EHR, the conduct of studies in healthcare settings, and the accurate delivery and evaluation of multiple intervention components with smokers at different phases of smoking treatment. The Implementation and Health Systems Integration Core will support the four proposed research projects by achieving four specific aims: 1) To support the development and implementation of an EHR enhanced to increase the documentation of smoking status and referral to smoking treatment for smokers visiting real-world primary care clinics. 2) To adapt, implement, and maintain a computerized database to prompt and track interventions and to ensure that research staff administer the appropriate study interventions and assessments for all four projects described in this Program Project application;3) To train all research staff to conduct all study interventions and assessments and to monitor competency and fidelity to study protocols;and 4) To support an integrated recruitment strategy to meet the recruitment goals for Projects 2-4 (N=1712 from 18 primary care clinics in three healthcare systems over 24 months). The achievement of these aims will be enhanced by the extensive prior experience of the Core investigators and staff in modifying EHRs, conducting research in healthcare settings, and conducting ambitious comparative effectiveness research on smoking treatments. This Core will ensure that the proposed work is conducted in a highly effective and timely manner.

Public Health Relevance

This Program Project is aimed at improving smoking treatment in healthcare settings through four ambitious research projects requiring the evaluation of multiple smoking treatments in healthcare settings. To support this, the Implementation Core will take steps to recruit smoker participants, train healthcare and research staff, secures needed resources, and ensure that treatments and assessments are accurately conducted.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-RPRB-0 (O2))
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University of Wisconsin Madison
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Loh, Wei-Yin; Fu, Haoda; Man, Michael et al. (2016) Identification of subgroups with differential treatment effects for longitudinal and multiresponse variables. Stat Med 35:4837-4855
Piper, Megan E; Fiore, Michael C; Smith, Stevens S et al. (2016) Identifying effective intervention components for smoking cessation: a factorial screening experiment. Addiction 111:129-41
Collins, Linda M; Kugler, Kari C; Gwadz, Marya Viorst (2016) Optimization of Multicomponent Behavioral and Biobehavioral Interventions for the Prevention and Treatment of HIV/AIDS. AIDS Behav 20 Suppl 1:S197-214
Schlam, Tanya R; Fiore, Michael C; Smith, Stevens S et al. (2016) Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment. Addiction 111:142-55
Adsit, Robert; Wisinski, Kari; Mattison, Ryan et al. (2016) A Survey of Baseline Tobacco Cessation Clinical Practices and Receptivity to Academic Detailing. WMJ 115:143-6
Watkins, Edward; Newbold, Alexandra; Tester-Jones, Michelle et al. (2016) Implementing multifactorial psychotherapy research in online virtual environments (IMPROVE-2): study protocol for a phase III trial of the MOST randomized component selection method for internet cognitive-behavioural therapy for depression. BMC Psychiatry 16:345
Baker, Timothy B; Collins, Linda M; Mermelstein, Robin et al. (2016) Enhancing the effectiveness of smoking treatment research: conceptual bases and progress. Addiction 111:107-16
Cook, Jessica W; Collins, Linda M; Fiore, Michael C et al. (2016) Comparative effectiveness of motivation phase intervention components for use with smokers unwilling to quit: a factorial screening experiment. Addiction 111:117-28
Fiore, Michael C; Jorenby, Douglas E; Baker, Timothy B (2016) Don't Wait for COPD to Treat Tobacco Use. Chest 149:617-8
McCarthy, Danielle E; Ebssa, Lemma; Witkiewitz, Katie et al. (2015) Paths to tobacco abstinence: A repeated-measures latent class analysis. J Consult Clin Psychol 83:696-708

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