RESEARCH &RELATED - OTHER PROJECT INFORMATION - PROJECT SUMMARY/ABSTRACT The Administrative Core (Core A) is a centralized facility designed to manage all operations related to this PPG. It facilitates the interactions between the collaborating laboratories and is located within the Center for Drug Discovery (Northeastern University). During this cycle, the Administrative Core has been functioning very effectively. Suitable modifications were made to accommodate new directions and personnel changes. The major tasks of this Core component will continue to be: a) communicate the central scientific theme to which all component projects will direct their research efforts and maintain a focused approach while fulfilling the PPG's overall specific aims;b) manage the fiscal aspects of the PPG, maintain financial records and other administrative functions;and c) promptly and properly distribute or coordinate the distribution of materials (novel ligands;other ligands developed in the PI's laboratory;receptor mutants) produced under the auspices of Core B and the other projects. The Administrative Core also takes responsibility for synchronizing the operations and communications between the individual laboratories involved in the PPG and other laboratories which interact collaboratively at no cost to the project. This effort includes recording and distributing materials produced to the participant laboratories and to the collaborating laboratories, together with maintaining and updating the data base related to this collaborative effort. Additional specific coordinating efforts include maintaining regular telephone conferences, the yearly group meeting of participants and collaborators, as well as other communications and the quarterly meetings with the Internal Advisory Committee, as well as the yearly formal meeting with the External Scientific Advisory Committee. The Administrative Core will manage the shared resources that are required for the performance of the interrelated tasks for the individual research projects. General administrative support related to this Program Project, including financial management, correspondence and preparation of reports and proposals, will also be provided by this Core Facility. The administrative portion of this grant seeks to keep all three projects and Core B focused on the overall research goals and to enhance communication between each branch of the grant. It will enhance the ability of collaborating laboratories to focus on the central PPG's overall goal which is the development of therapies for addiction and pain.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
2P01DA009158-15A1
Application #
8742281
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2014-09-15
Budget End
2015-06-30
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Northeastern University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Järbe, Torbjörn U C; Gifford, Roger S; Zvonok, Alexander et al. (2016) [INCREMENT]9-Tetrahydrocannabinol discriminative stimulus effects of AM2201 and related aminoalkylindole analogs in rats. Behav Pharmacol 27:211-4
Deng, Liting; Lee, Wan-Hung; Xu, Zhili et al. (2016) Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems. Pharmacol Res 114:75-89
Schindler, Charles W; Redhi, Godfrey H; Vemuri, Kiran et al. (2016) Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys. Neuropsychopharmacology 41:2283-93
Dhopeshwarkar, Amey; Mackie, Ken (2016) Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway. J Pharmacol Exp Ther 358:342-51
Kulkarni, Pushkar M; Kulkarni, Abhijit R; Korde, Anisha et al. (2016) Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s). J Med Chem 59:44-60
Järbe, Torbjörn U C; LeMay, Brian J; Thakur, Ganesh A et al. (2016) A high efficacy cannabinergic ligand (AM4054) used as a discriminative stimulus: Generalization to other adamantyl analogs and Δ(9)-THC in rats. Pharmacol Biochem Behav 148:46-52
Carey, Lawrence M; Slivicki, Richard A; Leishman, Emma et al. (2016) A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Mol Pain 12:
Hua, Tian; Vemuri, Kiran; Pu, Mengchen et al. (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell 167:750-762.e14
Schindler, Charles W; Scherma, Maria; Redhi, Godfrey H et al. (2016) Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. Psychopharmacology (Berl) 233:1867-77
Panlilio, Leigh V; Thorndike, Eric B; Nikas, Spyros P et al. (2016) Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. Psychopharmacology (Berl) 233:1879-88

Showing the most recent 10 out of 182 publications