Abstract

The Administrative Core will provide administrative oversight of the entire Program Project. This will include not only budgetary and scientific oversight and coordination of individual Projects and the Behavioral Core, but also organization of meetings and interactions with the Scientific Advisory Committee [Drs. Kent Bemdge (University of Michigan), Regina Carelli (University of North Carolina) and Ron See (Medical University of South Carolina)], and coordination with our Statistical Advisor, Dr. Ed Rothman (University of Michigan).

Public Health Relevance

Addiction is a major public health problem in the United States. The goal of this Project is to use a preclinical model to delineate the psychological and neurobiological basis of individual differences in vulnerabilty to develop addiction-like behavior, as this will help identify risk factors that will aid in the development of targeting interventions and treatments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA031656-02
Application #
8458069
Study Section
Special Emphasis Panel (ZRG1-IFCN-H)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
2
Fiscal Year
2013
Total Cost
$37,990
Indirect Cost
$13,559

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Ahrens, Allison M; Ferguson, Lindsay M; Robinson, Terry E et al. (2018) Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence on the Form of the Reward Cue. eNeuro 5:
Sarter, Martin; Phillips, Kyra B (2018) The neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models. Behav Neurosci 132:1-12
Kawa, Alex B; Robinson, Terry E (2018) Sex differences in incentive-sensitization produced by intermittent access cocaine self-administration. Psychopharmacology (Berl) :
Singer, Bryan F; Fadanelli, Monica; Kawa, Alex B et al. (2018) Are Cocaine-Seeking ""Habits"" Necessary for the Development of Addiction-Like Behavior in Rats? J Neurosci 38:60-73
Mabrouk, Omar S; Han, John L; Wong, Jenny-Marie T et al. (2018) The in Vivo Neurochemical Profile of Selectively Bred High-Responder and Low-Responder Rats Reveals Baseline, Cocaine-Evoked, and Novelty-Evoked Differences in Monoaminergic Systems. ACS Chem Neurosci 9:715-724
Cogan, Elizabeth S; Shapses, Mark A; Robinson, Terry E et al. (2018) Disrupting reconsolidation: memory erasure or blunting of emotional/motivational value? Neuropsychopharmacology :
Pitchers, Kyle K; Kane, Louisa F; Kim, Youngsoo et al. (2017) 'Hot' vs. 'cold' behavioural-cognitive styles: motivational-dopaminergic vs. cognitive-cholinergic processing of a Pavlovian cocaine cue in sign- and goal-tracking rats. Eur J Neurosci 46:2768-2781
Singer, Bryan F; Bryan, Myranda A; Popov, Pavlo et al. (2017) Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine. Behav Brain Res 324:66-70
Pitchers, Kyle K; Phillips, Kyra B; Jones, Jonte L et al. (2017) Diverse Roads to Relapse: A Discriminative Cue Signaling Cocaine Availability Is More Effective in Renewing Cocaine Seeking in Goal Trackers Than Sign Trackers and Depends on Basal Forebrain Cholinergic Activity. J Neurosci 37:7198-7208
Turner, Cortney A; Flagel, Shelly B; Blandino Jr, Peter et al. (2017) Utilizing a unique animal model to better understand human temperament. Curr Opin Behav Sci 14:108-114

Showing the most recent 10 out of 48 publications