In substance abusers, the propensity to attribute incentive salience to cues and allow these cues to capture attention is thought to be causally related to response inhibition deficits, including cognitive and motor impulsivity, Aim 1 of Project 4 will characterize the attentional capacities of Sign Trackers (STs) and demonstrate that compared to Goal Trackers (GTs), STs exhibit a limited capacity to sustain attention and a propensity for impulsive responses. STs'attentional performance is hypothesized to be due to impaired top- down control mechanisms, including ineffective modification of performance in response to errors and reward loss.
Aim 2 concerns the prefrontal cholinergic mechanisms that mediate the relatively poor attentional performance of STs. Preliminary evidence is consistent with the hypothesis that prefrontal giutamatergic-cholinergic interactions are differently regulated in STs and contribute to their comparatively lower attentional performance.
Aim 3 will demonstrate that blocking a specific node in this circuit, presynaptic alpha4beta2* nAChRs expressed by thalamic afferents, causes ST-like performance impairments in GTs. Conversely, stimulation of alpha4beta2* nAChRs improves the attentional performance of STs.
Aim 4 will extend this research to the impact of cues that were associated with cocaine self- administration and are capable of producing addiction-like behavior and relapse. The presence of such a drug cue is expected to abolish the ability of STs to sustain cognitive performance, in part as a result of cue- evoked, excessively large and lasting prefrontal cholinergic transients that interfere with the detection of task signals. These drug cue-evoked, excessive release events also contribute to the relative inability of STs to re-engage in cognitive task performance. Collectively, this research is guided by the hypothesis that lower levels of cognitive control combined with attentional bias toward drug-related cues are key cognitive traits in individuals vulnerable for addiction. The neurochemical mechanisms underlying the detrimental efficacy of the drug cue in STs form the basis of therapeutic interventions designed to limit drug-cue evoked behavior and foster re-engagement in cognitive task performance (Aim 4).

Public Health Relevance

Addiction is a major public health problem in the United States. The goal of this Project is to use a preclinical model to delineate the psychological and neurobiological basis of individual differences in vulnerability to develop addiction-like behavior, as this will help identify risk factors that will aid in the development of targeting interventions and treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA031656-03
Application #
8638916
Study Section
Special Emphasis Panel (ZRG1-IFCN-H)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
3
Fiscal Year
2014
Total Cost
$273,164
Indirect Cost
$97,496
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Pitchers, Kyle K; Flagel, Shelly B; O'Donnell, Elizabeth G et al. (2015) Individual variation in the propensity to attribute incentive salience to a food cue: influence of sex. Behav Brain Res 278:462-9
Saunders, Benjamin T; O'Donnell, Elizabeth G; Aurbach, Elyse L et al. (2014) A cocaine context renews drug seeking preferentially in a subset of individuals. Neuropsychopharmacology 39:2816-23
Robinson, Terry E; Yager, Lindsay M; Cogan, Elizabeth S et al. (2014) On the motivational properties of reward cues: Individual differences. Neuropharmacology 76 Pt B:450-9
Sarter, Martin; Albin, Roger L; Kucinski, Aaron et al. (2014) Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. Exp Neurol 257:120-9
Meyer, Paul J; Cogan, Elizabeth S; Robinson, Terry E (2014) The form of a conditioned stimulus can influence the degree to which it acquires incentive motivational properties. PLoS One 9:e98163
Vander Weele, Caitlin M; Porter-Stransky, Kirsten A; Mabrouk, Omar S et al. (2014) Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery. Eur J Neurosci 40:3041-54
Sarter, Martin; Lustig, Cindy; Howe, William M et al. (2014) Deterministic functions of cortical acetylcholine. Eur J Neurosci 39:1912-20
Lesaint, Florian; Sigaud, Olivier; Flagel, Shelly B et al. (2014) Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations. PLoS Comput Biol 10:e1003466
Parker, Clarissa C; Chen, Hao; Flagel, Shelly B et al. (2014) Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology 76 Pt B:250-8
Saunders, Benjamin T; Yager, Lindsay M; Robinson, Terry E (2013) Preclinical studies shed light on individual variation in addiction vulnerability. Neuropsychopharmacology 38:249-50

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