The Behavioral Core will serve all individual Projects proposed in this application. In addition to the supervision of husbandry for all animals to be used in the Projects, there are a number of behavioral test procedures that are common to all Projects and these will be conducted in the Behavioral Core. This includes initial behavioral testing to quantify "traits" that are thought to contribute to vulnerability to addiction, including the propensity to attribute incentive salience to reward cues (measured by Pavlovian approach to reward cues) and the propensity to make "impulsive actions" (measured by premature responses on a 2-choice serial reaction time task). In addition, drug self-administration testing will be conducted in the Behavioral Core, when feasible and appropriate. The implementation of the Behavioral Core will insure a level of "quality control" and standardization that will significantly reduce variance and facilitate the comparison of results across individual Projects.
Addiction is a major public health problem in the United States. The goal of this Project is to use a preclinical model to delineate the psychological and neurobiological basis of individual differences in vulnerabilty to develop addiction-like behavior, as this will help identify risk factors that will aid in the development of targeting interventions and treatments.
|Sarter, Martin; Lustig, Cindy; Blakely, Randy D et al. (2016) Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility. J Physiol Paris 110:10-18|
|Ahrens, Allison M; Singer, Bryan F; Fitzpatrick, Christopher J et al. (2016) Rats that sign-track are resistant to Pavlovian but not instrumental extinction. Behav Brain Res 296:418-30|
|Singer, Bryan F; Guptaroy, Bipasha; Austin, Curtis J et al. (2016) Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function. Eur J Neurosci 43:662-70|
|Fitzpatrick, Christopher J; Perrine, Shane A; Ghoddoussi, Farhad et al. (2016) Sign-trackers have elevated myo-inositol in the nucleus accumbens and ventral hippocampus following Pavlovian conditioned approach. J Neurochem :|
|Gritton, Howard J; Howe, William M; Mallory, Caitlin S et al. (2016) Cortical cholinergic signaling controls the detection of cues. Proc Natl Acad Sci U S A 113:E1089-97|
|Ross, Shani E; Lehmann Levin, Emily; Itoga, Christy A et al. (2016) Deep brain stimulation in the central nucleus of the amygdala decreases 'wanting' and 'liking' of food rewards. Eur J Neurosci 44:2431-2445|
|Sarter, Martin; Lustig, Cindy; Berry, Anne S et al. (2016) What do phasic cholinergic signals do? Neurobiol Learn Mem 130:135-41|
|Kawa, Alex B; Bentzley, Brandon S; Robinson, Terry E (2016) Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior. Psychopharmacology (Berl) 233:3587-602|
|Ahrens, Allison M; Meyer, Paul J; Ferguson, Lindsay M et al. (2016) Neural Activity in the Ventral Pallidum Encodes Variation in the Incentive Value of a Reward Cue. J Neurosci 36:7957-70|
|Fraser, Kurt M; Haight, Joshua L; Gardner, Eliot L et al. (2016) Examining the role of dopamine D2 and D3 receptors in Pavlovian conditioned approach behaviors. Behav Brain Res 305:87-99|
Showing the most recent 10 out of 33 publications