Abstract

This core includes the data management, statistical analysis and administrative support for the grant and describes the patient population utilized in all patient-based sections of the program. The families with autosomal dominant polycystic kidney disease (ADPKD) who have been collected for more than 30 years at the University of Colorado are a unique resource for the study of human ADPKD. The historical, physical examination, laboratory and imaging data of these subjects are entered into the PKD database and have been extensively analyzed. The data management and statistical section is engaged in data entry, data verification and statistical analysis support for the entire program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK034039-17
Application #
6604757
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
17
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Perrone, Ronald D; Mouksassi, Mohamad-Samer; Romero, Klaus et al. (2017) Total Kidney Volume Is a Prognostic Biomarker of Renal Function Decline and Progression to End-Stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 2:442-450
Perrone, Ronald D; Mouksassi, Mohamad-Samer; Romero, Klaus et al. (2017) A Drug Development Tool for Trial Enrichment in Patients With Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 2:451-460
Nowak, Kristen L; Cadnapaphornchai, Melissa A; Chonchol, Michel B et al. (2016) Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol 44:171-8
Schrier, Robert W; Abebe, Kaleab Z; Perrone, Ronald D et al. (2014) Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med 371:2255-66
Helal, Imed; Reed, Berenice; Mettler, Pamela et al. (2012) Prevalence of cardiovascular events in patients with autosomal dominant polycystic kidney disease. Am J Nephrol 36:362-70
Reed, Berenice Y; Masoumi, Amirali; Elhassan, Elwaleed et al. (2011) Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. Kidney Int 79:128-34
Helal, Imed; Reed, Berenice; McFann, Kim et al. (2011) Glomerular hyperfiltration and renal progression in children with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 6:2439-43
Reed, Berenice; McFann, Kim; Kimberling, William J et al. (2008) Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history. Am J Kidney Dis 52:1042-50
Reed, Berenice Y; McFann, Kim; Bekheirnia, Mir R et al. (2008) Variation in age at ESRD in autosomal dominant polycystic kidney disease. Am J Kidney Dis 51:173-83
Tao, Yunxia; Zafar, Iram; Kim, Jun et al. (2008) Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J Am Soc Nephrol 19:749-55

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