The Biostatistics Core (Core B) has been involved in the lithotripsy program project since its inception, providing data management expertise and statistical support to the team of multidisciplinary researchers In assessing the impact of shock wave lithotripsy on renal function and developing new treatment protocols . The specific alms for the Statistics Core for the next five years are:
Aim 1 : Provide statistical support to Investigators of this program project to ensure that appropriate study design and sufficient sample sizes with adequate statistical power are used in all experiments.
Aim 2 : Conduct statistical analyses of experimental data ensuring appropriate statistical models and techniques are used in analyzing each data set. Provide statistical support for accurate presentation of analysis results in reports and publications.
Aim 3 : Develop new statistical methodology to address challenging statistical issues related to both experimental design and data analyses that arise from this research program. The continued involvement of the Biostatistics Core in this research project will ensure that all experiments are conducted with appropriate design and adequate sample size, data are analyzed with appropriate statistical technique, and results are presented accurately with sufficient statistical details.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK043881-19
Application #
8484830
Study Section
Special Emphasis Panel (ZDK1-GRB-R)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$100,396
Indirect Cost
$54,922
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Janssen, Karmon M; Brand, Timothy C; Bailey, Michael R et al. (2018) Effect of Stone Size and Composition on Ultrasonic Propulsion Ex Vivo. Urology 111:225-229
Simon, Julianna C; Sapozhnikov, Oleg A; Kreider, Wayne et al. (2018) The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact. Phys Med Biol 63:025011
Matula, Thomas J; Sapozhnikov, Oleg A; Ostrovsky, Lev A et al. (2018) Ultrasound-based cell sorting with microbubbles: A feasibility study. J Acoust Soc Am 144:41
Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192
Sapozhnikov, Oleg; Nikolaeva, Anastasiia; Bailey, Michael (2018) The effect of shear waves in an elastic sphere on the radiation force from a quasi-Gaussian beam. Proc Meet Acoust 32:
Zwaschka, Theresa A; Ahn, Justin S; Cunitz, Bryan W et al. (2018) Combined Burst Wave Lithotripsy and Ultrasonic Propulsion for Improved Urinary Stone Fragmentation. J Endourol 32:344-349
Connors, Bret A; Schaefer, Ray B; Gallagher, John J et al. (2018) Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device. Urology 116:213-217
Dai, Jessica C; Dunmire, Barbrina; Sternberg, Kevan M et al. (2018) Retrospective comparison of measured stone size and posterior acoustic shadow width in clinical ultrasound images. World J Urol 36:727-732
Rosnitskiy, Pavel B; Yuldashev, Petr V; Sapozhnikov, Oleg A et al. (2017) Design of HIFU Transducers for Generating Specified Nonlinear Ultrasound Fields. IEEE Trans Ultrason Ferroelectr Freq Control 64:374-390
Li, Guangyan; Connors, Bret A; Schaefer, Ray B et al. (2017) Evaluation of an experimental electrohydraulic discharge device for extracorporeal shock wave lithotripsy: Pressure field of sparker array. J Acoust Soc Am 142:3147

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