Shock wave lithotripsy (SWL) is a widely used noninvasive procedure to break symptomatic kidney stones, with more than 300,000 treatments annually in the U.S. Though SWL is appealing as a noninvasive treatment option, repeat treatments and/or ancillary invasive procedures are commonly required to render the patient entirely stone free. Indeed, SWL is successful in only about 50% of cases. In addition to relatively low success rates, SWL can cause injury to the kidney and surrounding tissues that can have serious consequences. In Project 2, we build on understanding of the mechanisms of stone fragmentation in SWL to design a related, but fundamentally distinct, noninvasive treatment to reliably and safely break stones into uniformly small fragments that are passable and clinically insignificant. This new burst wave lithotripsy (BWL) approach delivers several- cycle bursts of sub-megahertz ultrasound without shocks, using pressure amplitudes significantly lower than those in SWL. Preliminary studies with a 170 kHz transducer demonstrate that BWL breaks both artificial and natural stones (calcium oxalate monohydrate, uric acid, struvite, cystine) into more uniformly small fragments than SWL, faster than clinical SWL. Parallel studies at higher frequencies suggest that fragment sizes are controlled by the ultrasound frequency. Beyond stone fragmentation, initial in vivo experiments indicate that stones can be broken using BWL parameters that induce almost no injury in pig kidneys. The overarching objective of this effort is to advance BWL toward clinical use. Relevant parameters for BWL treatment include the ultrasound frequency and amplitude, the number of acoustic cycles in each ultrasound burst, and the rate at which bursts are delivered. The first three Aims of this proposal seek to design effective and safe BWL treatment protocols with these parameters by (1) testing for optimal conditions to efficiently break stones into easily passable (<1 mm) fragments;(2) identifying and modeling mechanisms for stone comminution and tissue injury to improve the procedure by direct exploration of the parameter space;and (3) evaluating the injury potential of BWL treatments with in vivo testing on the pig model. With design inputs from these three Aims, the goal of Aim (4) is to develop and test a pre-clinical BWL prototype. The proposed studies are designed synergistically with both the Project 1 studies on ultrasound-based technologies for stone imaging and manipulation and the Project 3 studies on acoustic cavitation injury. The work will benefit public health by providing a novel strategy for non-invasive extracorporeal lithotripsy (without shock waves) that will lead to faster, safer, more effective clinical treatments with improved outcomes for stone patients.

Public Health Relevance

With kidney stones affecting about 1 in 11 Americans, shock wave lithotripsy (SWL) is a very common noninvasive treatment that, when effective, uses shocked sound waves to break stones into small fragments that can pass naturally. However, retreatment rates remain high and more invasive procedures are gaining popularity. This proposal seeks to develop an alternative noninvasive treatment (Burst Wave Lithotripsy, BWL) that utilizes ultrasound without shock waves to reliably break stones into uniformly small fragments more quickly and more safely than SWL.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK043881-20
Application #
8740045
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-09-16
Budget End
2015-06-30
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
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