Core B, the Molecular Pathology and Imaging Core (MPIC;formerly the Morphology Core), was established in 1995 as a part of this Program Project and been heavily utilized and extremely successful since its inception, serving as a model core facility for numerous other program projects and centers at the University of Pennsylvania and throughout the country. The overarching goal of MPIC is to provide exceptional service and support to the P01 investigators and their laboratories for the preparation and analyses of tissue sections and cultured cells. MPIC is lead by an experienced Director and Technical Director and is a unique entity at the University of Pennsylvania, with specific expertise in processing and analyses of all tissue types relevant to this P01. As such, MPIC continues to provide essential services to P01 members by offering specialized and high quality tissue preparation, instruction in morphological examination, and the equipment necessary for all of the protocols. MPIC also fosters cost-effective approaches and promotes new and exciting directions for research. Members of this P01 receive subsidies for use of MPIC and are provided with immunohistochemistry services not available to investigators who are not P01 members. Since the last submission of this application, we have continued to incorporate and integrate new services and technologies, and, reflective of these changes and the services currently provided to our users, have changed the name of the core from the Morphology Core to the Molecular Pathology and Imaging Core. Recent enhancements include nearly 500 square feet of additional space, upgrade of a Yokagawa CSU-10 spinning disk confocal scanner which is now equipped for live-cell imaging, incorporation of on-line scheduling and ordering, and acquisition of a DAKO autostainer. Thus, MPIC provides exceptional utility, quality, value, experience, service, and commitment to this P01.
The Molecular Pathology and Imaging Core (MPIC;formerly the Morphology Core), continues to support all projects of this P01 by providing necessary, specialized, and high quality services, consultation, and equipment. As such, MPIC assists the investigators of this Program Project in their studies of Integrative Metabolic Adaptions to Environmental and Nutritional Challenge.
|Park, Hyeong-Kyu; Ahima, Rexford S (2015) Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism 64:24-34|
|Soleimanpour, Scott A; Gupta, Aditi; Bakay, Marina et al. (2014) The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 157:1577-90|
|Jiang, Shaoning; Park, Dae Won; Tadie, Jean-Marc et al. (2014) Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol 192:4795-803|
|Lee, Dolim; Le Lay, John; Kaestner, Klaus H (2014) The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice. Diabetologia 57:1242-8|
|Lee, Sahmin; Lee, Hyun-Chae; Kwon, Yoo-Wook et al. (2014) Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes. Cell Metab 19:484-97|
|Baur, Joseph A; Birnbaum, Morris J (2014) Control of gluconeogenesis by metformin: does redox trump energy charge? Cell Metab 20:197-9|
|Shin, Soona; Kaestner, Klaus H (2014) The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Curr Top Dev Biol 107:269-92|
|Roat, Regan; Rao, Vandana; Doliba, Nicolai M et al. (2014) Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice. PLoS One 9:e86815|
|Liew, Chong Wee; Assmann, Anke; Templin, Andrew T et al. (2014) Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ? cells. Proc Natl Acad Sci U S A 111:E2319-28|
|Carr, Rotonya M; Peralta, Giselle; Yin, Xiaoyan et al. (2014) Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice. PLoS One 9:e97118|
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