Abstract

The gene expression Core will permit a high-throughput, high-resolution analysis of gene expression in the developing skeleton. This core will perform two genome-wide screens of broad interest and utility to map the expression of all transcriptional regulators, ligands and their cognate receptors in the context of the developing mouse skeleton. Further, we will perform a rapid analysis of large data sets emerging from transcriptional profiling approaches addressing underlying molecular mechanisms of skeletogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK056246-09
Application #
7632215
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
9
Fiscal Year
2008
Total Cost
$35,078
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Chen, J W; Galloway, J L (2017) Using the zebrafish to understand tendon development and repair. Methods Cell Biol 138:299-320
He, Xinjun; Bougioukli, Sofia; Ortega, Brandon et al. (2017) Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone. Bone 103:12-19
Hojo, Hironori; McMahon, Andrew P; Ohba, Shinsuke (2016) An Emerging Regulatory Landscape for Skeletal Development. Trends Genet 32:774-787
Finch, Caleb E; McMahon, Andrew P (2016) Stem cells for all ages, yet hostage to aging. Stem Cell Investig 3:11
Hojo, Hironori; Ohba, Shinsuke; He, Xinjun et al. (2016) Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification. Dev Cell 37:238-53
He, Xinjun; Ohba, Shinsuke; Hojo, Hironori et al. (2016) AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development 143:3012-23
Moore, Talia Y; Organ, Chris L; Edwards, Scott V et al. (2015) Multiple phylogenetically distinct events shaped the evolution of limb skeletal morphologies associated with bipedalism in the jerboas. Curr Biol 25:2785-2794
Ohba, Shinsuke; He, Xinjun; Hojo, Hironori et al. (2015) Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Rep 12:229-43
Kozhemyakina, Elena; Zhang, Minjie; Ionescu, Andreia et al. (2015) Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol 67:1261-73
Hirai, Takao; Kobayashi, Tatsuya; Nishimori, Shigeki et al. (2015) Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology 156:2774-80

Showing the most recent 10 out of 79 publications