The Administrative Core provides strong centralized scientific and administrative leadership to the PPG, which facilitates synergistic interactions between the four projects and the other core and maintains the overall focus of the program project. Dr. Fabio Cominelli, Program Director, has primary responsibility for all aspects of the program. He will be assisted by the Executive Committee (project and core leaders), as well as the Internal and Extemal Advisory Boards. This core will oversee all annual budgets, monitor expenses and provide monthly statements of financial activities to the four projects and two cores. In addition, all program-related meetings will be scheduled through the core. These include the bi-weekly meeting of the Executive Committee to evaluate productivity, allocation of core usage, and program resources, discussions of future directions as well as presentation of research in progress, identification of problems and discussion of alternative approaches and solutions. The Adminstrative Core will also offer centralized biostatistical and manuscript support to all the projects. The enrichment program ofthe Administrative Core will arrange for the Annual Meeting of the Extemal Advisory Board as well as the Annual Intemational Scientific Workshop. In addition, generation of materials to be reviewed by the Advisory Boards will be handled through the Administrative Core. Finally, the Administrative Core will prepare, generate and assemble materials required for the annual progress reports and will insure that all additional NIH and institutional reporting requirements concerning PPG activities are fulfilled in a timely manner.
CD affects more than 500,000 individuals in the US and incurs significant costs to society. Understanding the precise mechanisms and immune defects that cause the disease will allow us to develop better therapies and begin to develop a cure for this devastating disease.
|Chirieleison, Steven M; Marsh, Rebecca A; Kumar, Prathna et al. (2017) Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. J Biol Chem 292:9666-9679|
|Menghini, Paola; Di Martino, Luca; Lopetuso, Loris R et al. (2017) A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. PLoS One 12:e0174121|
|Do, Jeong-Su; Kim, Sohee; Keslar, Karen et al. (2017) ?? T Cells Coexpressing Gut Homing ?4?7 and ?E Integrins Define a Novel Subset Promoting Intestinal Inflammation. J Immunol 198:908-915|
|Cominelli, Fabio; Arseneau, Kristen O; Rodriguez-Palacios, Alexander et al. (2017) Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model? Cell Mol Gastroenterol Hepatol 4:19-32|
|Rathkey, Joseph K; Benson, Bryan L; Chirieleison, Steven M et al. (2017) Live-cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem 292:14649-14658|
|Corridoni, D; Rodriguez-Palacios, A; Di Stefano, G et al. (2017) Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis. Mucosal Immunol 10:971-982|
|Ley, Klaus; Rivera-Nieves, Jesus; Sandborn, William J et al. (2016) Integrin-based therapeutics: biological basis, clinical use and new drugs. Nat Rev Drug Discov 15:173-83|
|Grivennikov, Sergei I; Cominelli, Fabio (2016) Colitis-Associated and Sporadic Colon Cancers: Different Diseases, Different Mutations? Gastroenterology 150:808-10|
|Goodman, W A; Omenetti, S; Date, D et al. (2016) KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation. Mucosal Immunol 9:1250-62|
|Basson, Abigail; Trotter, Ashley; Rodriguez-Palacios, Alex et al. (2016) Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol 7:290|
Showing the most recent 10 out of 76 publications