Abstract

This proposal is directeed to the investigation of the toxicology of environmental chemicals. Research will be undertaken on an interdisciplinary basis under the following objectives: 1) To determine the biochemical reactions and interactions of exogenous chemicals in producing effects in biological systems. 2) Investigate the direct and combined effect of environmental chemicals on the production and course of neoplasia in animals. 3) To determine the physical chemical properties and chemodynamic data of chemicals and develop new and more sensitive analytical methods for potentially hazardous contaminants. The work involves 12 investigators and a number of disciplines. They intend to pursue studies on molecular and biochemical mechanisms whereby xenobiotics effect levels of gluthathion and related thiols induction of porphyria and membrane function and structure. The role of chemicals in the production and course neoplasia in animals will be followed. New and more sensitive methods of analyses for certain contaminants and potentially hazardous chemicals will be developed. In addition, photochemistry of many of these chemicals will be determined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES000040-27
Application #
3095747
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1974-11-01
Project End
1992-11-30
Budget Start
1990-12-01
Budget End
1991-11-30
Support Year
27
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Oregon State University
Department
Type
Organized Research Units
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339

  Publications

Ehrlich, Allison K; Pennington, Jamie M; Tilton, Susan et al. (2017) AhR activation increases IL-2 production by alloreactive CD4+ T cells initiating the differentiation of mucosal-homing Tim3+ Lag3+ Tr1 cells. Eur J Immunol 47:1989-2001
Ehrlich, Allison K; Pennington, Jamie M; Wang, Xisheng et al. (2016) Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol 196:264-73
Venkataraman, Anand; Coleman, Daniel J; Nevrivy, Daniel J et al. (2014) Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation. Photochem Photobiol Sci 13:531-40
Viera, Liliana; Radmilovich, Milka; Vargas, Marcelo R et al. (2013) Temporal patterns of tyrosine nitration in embryo heart development. Free Radic Biol Med 55:101-8
Venkataraman, Anand; Nevrivy, Daniel J; Filtz, Theresa M et al. (2012) Grp1-associated scaffold protein (GRASP) is a regulator of the ADP ribosylation factor 6 (Arf6)-dependent membrane trafficking pathway. Cell Biol Int 36:1115-28
Traber, Maret G; Mustacich, Debbie J; Sullivan, Laura C et al. (2010) Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice. J Nutr Biochem 21:1193-9
Marshall, Nikki B; Kerkvliet, Nancy I (2010) Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells. Ann N Y Acad Sci 1183:25-37
Vassallo, Jeffrey D; Kaetzel, Rhonda S; Born, Stephanie L et al. (2010) Gamma-glutamyl transpeptidase null mice fail to develop tolerance to coumarin-induced Clara cell toxicity. Food Chem Toxicol 48:1612-8
Kerkvliet, Nancy I; Steppan, Linda B; Vorachek, William et al. (2009) Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy 1:539-47
Kerkvliet, Nancy I (2009) AHR-mediated immunomodulation: the role of altered gene transcription. Biochem Pharmacol 77:746-60

Showing the most recent 10 out of 79 publications