During the past 10 years, the Community-Based Participatory Research Project (CBPR) of our Center has worked with community groups and individuals to examine the take-home pathway of pesticide exposure among children of farmworkers in Yakima Valley. The CBPR study provided evidence that demonstrated children's exposure through a para-occupational pathway and in the previous 5 years of this Center grant, the CBPR Research Project conducted a community based intervention project (CIP) that identified and successfully implemented an intervention reducing the occupational take home pesticide exposure pathway for families and their children. These findings led to a number of additional questions on the part of our community partners;specifically, are there other pathways of pesticide exposure and are non-farmworkers exposed to pesticides. This proposed renewal project is designed to find answers to these questions. In this project, the CPBR investigators will characterize the seasonal variability of organophosphate (OP) exposure across our cohort by sampling at times of peak OP usage and by evaluating OP metabolite profiles across time during these seasons;assess the influence of gene environment interactions on OP exposure and response profiles;and calculate the contributions from gene, environment and season to within-person and between-person variability of the urinary OP metabolites in farmworkers to identify quantitatively differences between persons and across seasons. Secondarily, CBPR investigators will build from the recent observations by our colleagues in the Pesticide Exposure Pathways Research project that measure parent and oxon concentration for 3 OPs during times of peak agricultural usages. The current studies revealed that measurable CP and CPO levels that were obtained were different than current air models would predict; further, they appear to contribute a proximity factor to our cohort exposure studies. Thus we will coordinate our cohort and household sampling with agricultural practices and field air monitoring.

Public Health Relevance

This project is designed to continue our partnership with our Yakima Valley farmworker cohort in order to characterize factors that contribute to within- and between-person variability in pesticide exposure response. This project will include evaluations of seasonal variability and influence of gene-environment interactions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES009601-15
Application #
8519439
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
15
Fiscal Year
2013
Total Cost
$30,585
Indirect Cost
$16,740
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Kim, Hee Yeon; Wegner, Susanna H; Van Ness, Kirk P et al. (2016) Differential epigenetic effects of chlorpyrifos and arsenic in proliferating and differentiating human neural progenitor cells. Reprod Toxicol 65:212-223
Smith, Marissa N; Grice, Joshua; Cullen, Alison et al. (2016) A Toxicological Framework for the Prioritization of Children's Safe Product Act Data. Int J Environ Res Public Health 13:431
Marsillach, Judit; Costa, Lucio G; Furlong, Clement E (2016) Paraoxonase-1 and Early-Life Environmental Exposures. Ann Glob Health 82:100-10
Holme, Francesca; Thompson, Beti; Holte, Sarah et al. (2016) The role of diet in children's exposure to organophosphate pesticides. Environ Res 147:133-40
Furlong, Clement E; Marsillach, Judit; Jarvik, Gail P et al. (2016) Paraoxonases-1, -2 and -3: What are their functions? Chem Biol Interact :
Peter, Beate; Wijsman, Ellen M; Nato Jr, Alejandro Q et al. (2016) Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. PLoS One 11:e0153864
Weldon, Brittany A; Shubin, Sara Pacheco; Smith, Marissa N et al. (2016) Urinary microRNAs as potential biomarkers of pesticide exposure. Toxicol Appl Pharmacol 312:19-25
Smith, Marissa N; Wilder, Carly S; Griffith, William C et al. (2015) Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region. Biomarkers 20:299-305
Harris, Sean; Hermsen, Sanne A B; Yu, Xiaozhong et al. (2015) Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. Reprod Toxicol 58:149-59
Wegner, Susanna H; Yu, Xiaozhong; Pacheco Shubin, Sara et al. (2015) Stage-specific signaling pathways during murine testis development and spermatogenesis: A pathway-based analysis to quantify developmental dynamics. Reprod Toxicol 51:31-9

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