The Research Development Core will bring new investigators into the NIEHS Center for Neurodegeneration Science (CMS) team, studying in particular environmental stressors contributing to Parkinson's disease, by offering support for the initial development of novel lines of investigation that complement the ongoing research projects of this Center. Below, we describe the process of soliciting, reviewing, and awarding and monitoring the progress of these pilot projects. Importantly, to be eligible to obtain one of these pilot awards, the applicant will have no current affiliation with the proposed NIEHS Center. We plan to award three grants per annum, each at $25,000 for a total of $75,000 as suggested in the RFA. We will particularly embrace promising new directions of junior trainees as well as established faculty who wish to enter this field in order to link environmental sciences with neurodegenerative conditions, particularly with the Parkinson's disease (PD) focus proposed for this Center. We believe that the multidisciplinary research environment, well-organized and highly integrated infrastructure, and the rich longitudinal specimen and human data bank found in Core E (Neuropathology/Behavior Core) will foster services that cannot be found anywhere else in Southern California, creating an inviting environment for investigators to enter the field. The new investigators will participate in our weekly laboratory meetings and monthly sessions for the entire Center, as described in detail in the grant Introduction and in Core A (Administrative Core).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES016738-05
Application #
8377590
Study Section
Special Emphasis Panel (ZES1-LWJ-G)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$155,641
Indirect Cost
$69,943
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Oh, Chang-Ki; Sultan, Abdullah; Platzer, Joseph et al. (2017) S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models. Cell Rep 21:2171-2182
Singec, Ilyas; Crain, Andrew M; Hou, Junjie et al. (2016) Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports 7:527-542
Qu, Zhe; Greenlief, C Michael; Gu, Zezong (2016) Quantitative Proteomic Approaches for Analysis of Protein S-Nitrosylation. J Proteome Res 15:1-14
Spiering, Sean; Davidovics, Herman; Bushway, Paul J et al. (2015) High content screening for modulators of cardiac differentiation in human pluripotent stem cells. Methods Mol Biol 1263:43-61
Okamoto, Shu-ichi; Lipton, Stuart A (2015) S-Nitrosylation in neurogenesis and neuronal development. Biochim Biophys Acta 1850:1588-93
Satoh, Takumi; Stalder, Romain; McKercher, Scott R et al. (2015) Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential. ASN Neuro 7:
Zhou, Hui; Qu, Zhe; Mossine, Valeri V et al. (2014) Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells. PLoS One 9:e113531
Chan, Shing Fai; Sances, Sam; Brill, Laurence M et al. (2014) ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci 34:4640-53
Okamoto, Shu-Ichi; Nakamura, Tomohiro; Cieplak, Piotr et al. (2014) S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep 8:217-28
Qu, Zhe; Meng, Fanjun; Zhou, Hui et al. (2014) NitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells. J Neuroinflammation 11:17

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