The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related contaminants, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs), genetic and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide; Project 2 (Exposure Assessment for Childhood Leukemia) y/ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs; Project 3 (Prenatal exposures, DNA Methylation, & Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities; 2) scientific leadership; and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees; appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pedicatric Health Specialists

Public Health Relevance

The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes. Core A will provide centralized scientific, administrative, and data management support to implement/coordinate the Research Projects and Research Translational and Community Outreach Core.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LKB-G (P1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Berkeley
United States
Zip Code
Morimoto, Libby M; McCauley, Kathryn; Ma, Xiaomei et al. (2016) Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Ann Epidemiol 26:141-5
Lee, Seung-Tae; Wiemels, Joseph L (2016) Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. Nucleic Acids Res 44:1105-17
Metayer, Catherine; Petridou, Eleni; Aranguré, Juan Manuel Mejía et al. (2016) Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium. Am J Epidemiol 184:261-73
Triebwasser, Corey; Wang, Rong; DeWan, Andrew T et al. (2016) Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California. Eur J Cancer 69:19-27
Marcotte, Erin L; Thomopoulos, Thomas P; Infante-Rivard, Claire et al. (2016) Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC). Lancet Haematol 3:e176-85
Whitehead, Todd P; Metayer, Catherine; Wiemels, Joseph L et al. (2016) Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care 46:317-352
Whitehead, Todd P; Crispo Smith, Sabrina; Park, June-Soo et al. (2015) Concentrations of persistent organic pollutants in California women's serum and residential dust. Environ Res 136:57-66
Zachek, Christine M; Miller, Mark D; Hsu, Christopher et al. (2015) Children's Cancer and Environmental Exposures: Professional Attitudes and Practices. J Pediatr Hematol Oncol 37:491-7
Gonseth, Semira; Roy, Ritu; Houseman, E Andres et al. (2015) Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics 10:1166-76
Bailey, Helen D; Metayer, Catherine; Milne, Elizabeth et al. (2015) Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium. Cancer Causes Control 26:1257-70

Showing the most recent 10 out of 35 publications