Although mouse allergen and pollutant exposures have been linked to asthma morbidity in poor minority populations, these factors do not account for most of the observed morbidity, so that additional environmental factors almost certainly contribute to asthma morbidity in this population. One intriguing environmental factor is diet since the population that is most affected by asthma morbidity and mortality-poor, predominantly African American populations- have a

Public Health Relevance

Findings from the proposed studies will lend insight into impact of dietary factors on inner-city asthma. Specifically, the project will determine if dietary interventions can improve oxidative stress status, inflammation, and allergic asthma. The findings may support the use of dietary supplement or overhaul of diet in the treatment of allergic asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018176-05
Application #
8528591
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$150,848
Indirect Cost
$46,070
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Kolahdooz, Fariba; Butler, Jennie L; Christiansen, Karina et al. (2016) Food and Nutrient Intake in African American Children and Adolescents Aged 5 to 16 Years in Baltimore City. J Am Coll Nutr 35:205-16
Lu, Kim D; Phipatanakul, Wanda; Perzanowski, Matthew S et al. (2016) Atopy, but not obesity is associated with asthma severity among children with persistent asthma. J Asthma 53:1033-44
Sudini, Kuladeep; Diette, Gregory B; Breysse, Patrick N et al. (2016) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics. J Allergy Clin Immunol Pract 4:932-40
Davis, Meghan F; Peng, Roger D; McCormack, Meredith C et al. (2015) Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults. J Allergy Clin Immunol 135:811-3.e5
Sussan, Thomas E; Gajghate, Sachin; Chatterjee, Samit et al. (2015) Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol 309:L27-36
Brigham, Emily P; Kolahdooz, Fariba; Hansel, Nadia et al. (2015) Association between Western diet pattern and adult asthma: a focused review. Ann Allergy Asthma Immunol 114:273-80
Brigham, Emily P; McCormack, Meredith C; Takemoto, Clifford M et al. (2015) Iron status is associated with asthma and lung function in US women. PLoS One 10:e0117545
Keet, Corinne A; McCormack, Meredith C; Pollack, Craig E et al. (2015) Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. J Allergy Clin Immunol 135:655-62
McCormack, Meredith C; Belli, Andrew J; Kaji, Deepak A et al. (2015) Obesity as a susceptibility factor to indoor particulate matter health effects in COPD. Eur Respir J 45:1248-57
Peng, Roger D; Butz, Arlene M; Hackstadt, Amber J et al. (2015) Estimating the health benefit of reducing indoor air pollution in a randomized environmental intervention. J R Stat Soc Ser A Stat Soc 178:425-443

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