Although mouse allergen and pollutant exposures have been linked to asthma morbidity in poor minority populations, these factors do not account for most of the observed morbidity, so that additional environmental factors almost certainly contribute to asthma morbidity in this population. One intriguing environmental factor is diet since the population that is most affected by asthma morbidity and mortality-poor, predominantly African American populations- have a

Public Health Relevance

Findings from the proposed studies will lend insight into impact of dietary factors on inner-city asthma. Specifically, the project will determine if dietary interventions can improve oxidative stress status, inflammation, and allergic asthma. The findings may support the use of dietary supplement or overhaul of diet in the treatment of allergic asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018176-05
Application #
8528591
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$150,848
Indirect Cost
$46,070
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Kim, Jung-Hyun; Thimmulappa, Rajesh K; Kumar, Vineet et al. (2014) NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest 124:730-41
Kaji, Deepak A; Belli, Andrew J; McCormack, Meredith C et al. (2014) Indoor pollutant exposure is associated with heightened respiratory symptoms in atopic compared to non-atopic individuals with COPD. BMC Pulm Med 14:147
Camargo Jr, Carlos A; Budinger, G R Scott; Escobar, Gabriel J et al. (2014) Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc 11 Suppl 3:S125-38
Okelo, Sande O; Riekert, Kristin A; Eakin, Michelle N et al. (2014) Pediatrician qualifications and asthma management behaviors and their association with patient race/ethnicity. J Asthma 51:155-61
Matsui, E C (2014) Environmental exposures and asthma morbidity in children living in urban neighborhoods. Allergy 69:553-8
Hackstadt, Amber J; Matsui, Elizabeth C; Williams, D'Ann L et al. (2014) Inference for environmental intervention studies using principal stratification. Stat Med 33:4919-33
Little, Frédéric F; Delgado, Diana M; Wexler, Philip J et al. (2014) Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma. PLoS One 9:e84449
Rivera-Mariani, Felix E; Matsui, Elizabeth C; Breysse, Patrick N (2014) Performance of the halogen immunoassay to assess airborne mouse allergen-containing particles in a laboratory animal facility. J Expo Sci Environ Epidemiol 24:3-8
Sussan, Thomas E; Ingole, Vijendra; Kim, Jung-Hyun et al. (2014) Source of biomass cooking fuel determines pulmonary response to household air pollution. Am J Respir Cell Mol Biol 50:538-48
Soneja, Sutyajeet; Chen, Chen; Tielsch, James M et al. (2014) Humidity and gravimetric equivalency adjustments for nephelometer-based particulate matter measurements of emissions from solid biomass fuel use in cookstoves. Int J Environ Res Public Health 11:6400-16

Showing the most recent 10 out of 33 publications