Abstract

This Core will operate the exposure systems developed at National Jewish for the short-term exposures of cultured cells and rodents to physiologically relevant levels of ozone. In addition, the Core will respond to investigator requests for alterations of the systems to meet specific experimental requirements (e;g., ramping of ozone concentrations, correction of ozone concentration for altitude dilution effects, rocking of cultured cells). An important function of the Core will be to ensure that the ozone is confined to the experimental apparatus, thereby not endangering laboratory personnel. The Core also maintains the computerized data acquisition systems associated with the exposure units and modifies the internally written programs to meet invesfigator needs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018181-05
Application #
8529262
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$116,255
Indirect Cost
$41,748

  Institution

Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206

  Publications

Dutmer, Cullen M; Schiltz, Allison M; Freeman, Kristy L et al. (2018) Observed Home Dampness and Mold Are Associated with Sustained Spikes in Personal Exposure to Particulate Matter Less than 10 ?m in Diameter in Exacerbation-Prone Children with Asthma. Ann Am Thorac Soc 15:S131-S132
Yang, Ivana V; Richards, Adam; Davidson, Elizabeth J et al. (2017) The Nasal Methylome: A Key to Understanding Allergic Asthma. Am J Respir Crit Care Med 195:829-831
Yang, Ivana V; Pedersen, Brent S; Liu, Andrew H et al. (2017) The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol 139:1478-1488
Breton, Carrie V; Marsit, Carmen J; Faustman, Elaine et al. (2017) Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect 125:511-526
Alper, Scott; Warg, Laura A; De Arras, Lesly et al. (2016) Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria. Genetics 204:327-36
Dakhama, Azzeddine; Gelfand, Erwin W (2016) In Vivo Assessment of Airway Function in the Mouse Model. Methods Mol Biol 1442:219-30
Gabehart, Kelsa; Correll, Kelly A; Loader, Joan E et al. (2015) The lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4. Respir Res 16:117
Lai, Peggy S; Liang, Liming; Cibas, Edmund S et al. (2015) Alternate methods of nasal epithelial cell sampling for airway genomic studies. J Allergy Clin Immunol 136:1120-3.e4
Keet, Corinne A; McCormack, Meredith C; Pollack, Craig E et al. (2015) Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. J Allergy Clin Immunol 135:655-62
Szefler, Stanley J (2015) Advances in pediatric asthma in 2014: Moving toward a population health perspective. J Allergy Clin Immunol 135:644-52

Showing the most recent 10 out of 33 publications